TRP Channels: The Neglected Culprits in Breast Cancer Chemotherapy Resistance?

被引：1

作者：

Soussi, Mayar ^{[1
]}

Hasselsweiller, Alice ^{[1
]}

Gkika, Dimitra ^{[1
]}

机构：

[1] Univ Lille, CHU Lille, Canc Heterogene Plast & Resistance Therapies, CNRS,Inserm,UMR9020,U1277,CANTHER, F-59000 Lille, France

来源：

MEMBRANES | 2023年 / 13卷 / 09期

关键词：

breast cancer; TRP channels; chemotherapy; chemoresistance taxanes; anthracyclines; tamoxifen; DRUG-RESISTANCE; TAMOXIFEN RESISTANCE; DNA-DAMAGE; RECEPTOR; DOXORUBICIN; MECHANISMS; CELLS; INHIBITION; APOPTOSIS; ANTHRACYCLINES;

D O I：

10.3390/membranes13090788

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer is a major health concern worldwide, and resistance to therapies remains a significant challenge in treating this disease. In breast cancer, Transient Receptor Potential (TRP) channels are well studied and constitute key players in nearly all carcinogenesis hallmarks. Recently, they have also emerged as important actors in resistance to therapy by modulating the response to various pharmaceutical agents. Targeting TRP channels may represent a promising approach to overcome resistance to therapies in breast cancer patients.

引用

页数：13

共 67 条

[31] Enhanced cytotoxicity in triple-negative and estrogen receptor-positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel
Koh, David W.
Powell, Daniel P.
Blake, Steven D.
Hoffman, Joy L.
Hopkins, Mandi M.
Feng, Xiaoxing
[J]. ONCOLOGY REPORTS, 2015, 34 (03) : 1589 - 1598
[32] Kojima I, 2014, HANDB EXP PHARMACOL, V222, P247, DOI 10.1007/978-3-642-54215-2_10
[33] Synergic Effects of Doxorubicin and Melatonin on Apoptosis and Mitochondrial Oxidative Stress in MCF-7 Breast Cancer Cells: Involvement of TRPV1 Channels
Kosar, Pinar Aslan
Naziroglu, Mustafa
Ovey, Ishak Suat
Cig, Bilal
[J]. JOURNAL OF MEMBRANE BIOLOGY, 2016, 249 (1-2) : 129 - 140
[34] Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes
Lim, CC
Zuppinger, C
Guo, XX
Kuster, GM
Helmes, M
Eppenberger, HM
Suter, TM
Liao, RL
Sawyer, DB
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (09) : 8290 - 8299
[35] P53-DEPENDENT APOPTOSIS MODULATES THE CYTOTOXICITY OF ANTICANCER AGENTS
LOWE, SW
RULEY, HE
JACKS, T
HOUSMAN, DE
[J]. CELL, 1993, 74 (06) : 957 - 967
[36] Mechanisms of Drug Resistance in Cancer Chemotherapy
Luqmani, Y. A.
[J]. MEDICAL PRINCIPLES AND PRACTICE, 2005, 14 : 35 - 48
[37] Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance
Ma, Xin
Chen, Zhen
Hua, Dong
He, Dongxu
Wang, Linjun
Zhang, Peng
Wang, Junqi
Cai, Yanfei
Gao, Caiji
Zhang, Xiaodong
Zhang, Fangfang
Wang, Teng
Hong, Tingting
Jin, Linfang
Qi, Xiaowei
Chen, Shuxian
Gu, Xiaoting
Yang, Dangtong
Pan, Qiongxi
Zhu, Yifei
Chen, Yun
Chen, Daozhen
Jiang, Liwen
Han, Xiaofeng
Zhang, Yanyun
Jin, Jian
Yao, Xiaoqiang
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (17) : 6389 - 6394
[38] Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells
Ma, Xin
Cai, Yanfei
He, Dongxu
Zou, Chang
Zhang, Peng
Lo, Chun Yin
Xu, Zhenyu
Chan, Franky L.
Yu, Shan
Chen, Yun
Zhu, Ruiyu
Lei, Jianyong
Jin, Jian
Yao, Xiaoqiang
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (40) : 16282 - 16287
[39] Mansoori B, 2017, ADV PHARM BULL, V7, P339, DOI 10.15171/apb.2017.041
[40] Enhanced antitumor and anti-metastasis efficiency via combined treatment with CXCR4 antagonist and liposomal doxorubicin
Mei, Ling
Liu, Yayuan
Zhang, Qianyu
Gao, Huile
Zhang, Zhirong
He, Qin
[J]. JOURNAL OF CONTROLLED RELEASE, 2014, 196 : 324 - 331

← 1 2 3 4 5 6 7 →