Prognostic value and immune landscapes of immunogenic cell death-related lncRNAs in hepatocellular carcinoma

被引:2
作者
Chen, Wanying [1 ,2 ]
Shu, Kexin [2 ,3 ]
Cai, Chenxi [2 ,3 ]
Ding, Jiatong [2 ,3 ]
Zhang, Xin [1 ]
Zhang, Wenxiong [1 ]
Wang, Kang [4 ]
机构
[1] Nanchang Univ, Dept Thorac Surg, Affiliated Hosp 2, Nanchang 330006, Peoples R China
[2] Nanchang Univ, Jiangxi Med Coll, Nanchang 330006, Peoples R China
[3] Nanchang Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Nanchang, Peoples R China
[4] Nanchang Univ, Dept Tradit Chinese Med, Affiliated Hosp 2, Nanchang 330006, Peoples R China
基金
中国国家自然科学基金;
关键词
SIGNATURE; SYSTEM;
D O I
10.1042/BSR20230634
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Both immunogenic cell death (ICD) and long noncoding RNAs (lncRNAs) are strongly associated with tumor development, but the mechanism of action of ICD-associated lncRNAs in hepatocellular carcinoma (HCC) remains unclear.Methods: We collected data from 365 HCC patients from The Cancer Genome Atlas (TCGA) database. We formulated a prognostic signature of ICD-associated lncRNAs and a nomogram to predict prognosis. To explore the potential mechanisms and provide clinical guidance, survival analysis, enrichment analysis, tumor microenvironment analysis, tumor mutation burden (TMB), and drug sensitivity prediction were conducted based on the subgroups obtained from the risk score.Results: A prognostic signature of seven ICD-associated lncRNAs was constructed. Kaplan-Meier (K-M) survival curves showed a more unfavorable outcome in high-risk patients. The nomogram had a higher predictive value than the nomogram constructed without the risk model. Enrichment analysis confirmed that risk lncRNAs were closely associated with cell proliferation and mitosis. Most of the immune checkpoints currently used in therapy (e.g., PDCD1 and CTLA4) appeared to be elevated in high-risk patients. Tumor microenvironment analysis showed differential expression of lymphocytes (including natural killer cells, regulatory T cells, etc.) in the high-risk group. TMB had a higher incidence of mutations in the high-risk group (P=0.004). Chemotherapy drug sensitivity prediction provides effective guidelines for individual therapy. RT-qPCR of human HCC tissues verified the accuracy of the model.Conclusion: We constructed an effective prognostic signature for patients with HCC using seven ICD-lncRNAs, which provides guidance for the prognostic assessment and personalized treatment of patients.
引用
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页数:15
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共 35 条
[1]   Differential expression analysis for sequence count data [J].
Anders, Simon ;
Huber, Wolfgang .
GENOME BIOLOGY, 2010, 11 (10)
[2]   Hepatobiliary Cancers, Version 2.2021 [J].
Benson III, Al B. ;
D'Angelica, Michael I. ;
Abbott, Daniel E. ;
Anaya, Daniel A. ;
Anders, Robert ;
Are, Chandrakanth ;
Bachini, Melinda ;
Borad, Mitesh ;
Brown, Daniel ;
Burgoyne, Adam ;
Chahal, Prabhleen ;
Chang, Daniel T. ;
Cloyd, Jordan ;
Covey, Anne M. ;
Glazer, Evan S. ;
Goyal, Lipika ;
Hawkins, William G. ;
Iyer, Renuka ;
Jacob, Rojymon ;
Kelley, R. Kate ;
Kim, Robin ;
Levine, Matthew ;
Palta, Manisha ;
Park, James O. ;
Raman, Steven ;
Reddy, Sanjay ;
Sahai, Vaibhav ;
Schefter, Tracey ;
Singh, Gagandeep ;
Stein, Stacey ;
Vauthey, Jean-Nicolas ;
Venook, Alan P. ;
Yopp, Adam ;
McMillian, Nicole R. ;
Hochstetler, Cindy ;
Darlow, Susan D. .
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2021, 19 (05) :541-565
[3]   Avelumab and cetuximab as a therapeutic combination: An overview of scientific rationale and current clinical trials in cancer [J].
Bourhis, Jean ;
Stein, Alexander ;
de Boer, Jan Paul ;
Van den Eynde, Marc ;
Gold, Kathryn A. ;
Stintzing, Sebastian ;
Becker, Juergen C. ;
Moran, Michael ;
Schroeder, Andreas ;
Pennock, Gregory ;
Salmio, Satu ;
Esser, Regina ;
Ciardiello, Fortunato .
CANCER TREATMENT REVIEWS, 2021, 97
[4]   Immunogenic cell death-related risk signature predicts prognosis and characterizes the tumour microenvironment in lower-grade glioma [J].
Cai, Jiayang ;
Hu, Yuanyuan ;
Ye, Zhang ;
Ye, Liguo ;
Gao, Lun ;
Wang, Yixuan ;
Sun, Qian ;
Tong, Shiao ;
Yang, Ji'an ;
Chen, Qianxue .
FRONTIERS IN IMMUNOLOGY, 2022, 13
[5]   Long non-coding RNA-based signature for predicting prognosis of hepatocellular carcinoma [J].
Cao, Jie ;
Wu, Lili ;
Lei, Xin ;
Shi, Keqing ;
Shi, Liang ;
Shi, Yifen .
BIOENGINEERED, 2021, 12 (01) :673-681
[6]   An Angiogenic Gene Signature for Prediction of the Prognosis and Therapeutic Responses of Hepatocellular Carcinoma [J].
Ci, Hongfei ;
Wang, Xufeng ;
Shen, Keyu ;
Du, Wei ;
Zhou, Jiaming ;
Fu, Yan ;
Dong, Qiongzhu ;
Jia, Huliang .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (04)
[7]   Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma [J].
Cui, Yongping ;
Chen, Hongyan ;
Xi, Ruibin ;
Cui, Heyang ;
Zhao, Yahui ;
Xu, Enwei ;
Yan, Ting ;
Lu, Xiaomei ;
Huang, Furong ;
Kong, Pengzhou ;
Li, Yang ;
Zhu, Xiaolin ;
Wang, Jiawei ;
Zhu, Wenjie ;
Wang, Jie ;
Ma, Yanchun ;
Zhou, Yong ;
Guo, Shiping ;
Zhang, Ling ;
Liu, Yiqian ;
Wang, Bin ;
Xi, Yanfeng ;
Sun, Ruifang ;
Yu, Xiao ;
Zhai, Yuanfang ;
Wang, Fang ;
Yang, Jian ;
Yang, Bin ;
Cheng, Caixia ;
Liu, Jing ;
Song, Bin ;
Li, Hongyi ;
Wang, Yi ;
Zhang, Yingchun ;
Cheng, Xiaolong ;
Zhan, Qimin ;
Li, Yanhong ;
Liu, Zhihua .
CELL RESEARCH, 2020, 30 (10) :902-913
[8]   Prognostic value of antitumor drug targets prediction using integrated bioinformatic analysis for immunogenic cell death-related lncRNA model based on stomach adenocarcinoma characteristics and tumor immune microenvironment [J].
Ding, Dayong ;
Zhao, Yan ;
Su, Yanzhuo ;
Yang, Huaixi ;
Wang, Xuefeng ;
Chen, Lin .
FRONTIERS IN PHARMACOLOGY, 2022, 13
[9]   Detecting Genomic Signatures of Natural Selection with Principal Component Analysis: Application to the 1000 Genomes Data [J].
Duforet-Frebourg, Nicolas ;
Luu, Keurcien ;
Laval, Guillaume ;
Bazin, Eric ;
Blum, Michael G. B. .
MOLECULAR BIOLOGY AND EVOLUTION, 2016, 33 (04) :1082-1093
[10]   Hepatocellular carcinoma in viral and autoimmune liver diseases: Role of CD4+CD25+Foxp3+regulatory T cells in the immune microenvironment [J].
Granito, Alessandro ;
Muratori, Luigi ;
Lalanne, Claudine ;
Quarneti, Chiara ;
Ferri, Silvia ;
Guidi, Marcello ;
Lenzi, Marco ;
Muratori, Paolo .
WORLD JOURNAL OF GASTROENTEROLOGY, 2021, 27 (22) :2994-3009