Suitable biomarkers for post-mortem differentiation of cardiac death causes: Quantitative analysis of miR-1, miR-133a and miR-26a in heart tissue and whole blood

被引：1

作者：

Mildeberger, Luise ^{[1
]}

Bueto, Julia ^{[1
]}

Wilmes, Verena ^{[1
]}

Scheiper-Welling, Stefanie ^{[1
]}

Niess, Constanze ^{[1
]}

Gradhand, Elise ^{[2
]}

Verhoff, Marcel A. ^{[1
]}

Kauferstein, Silke ^{[1
]}

机构：

[1] Goethe Univ, Univ Hosp Frankfurt, Inst Legal Med, Frankfurt Am Main, Germany

[2] Goethe Univ Frankfurt, Univ Hosp, Inst Pathol, D-60054 Frankfurt Am Main, Germany

来源：

FORENSIC SCIENCE INTERNATIONAL-GENETICS | 2023年 / 65卷

关键词：

Sudden unexpected death; Sudden cardiac death; Sudden infant death; Myocardial infarction; MicroRNAs; Biomarkers; Quantitative analysis; Whole blood; FFPE tissue; CARDIOVASCULAR-DISEASE; CIRCULATING MICRORNAS; EXPRESSION; GENETICS; AUTOPSY; SERUM; MIRNA;

D O I：

10.1016/j.fsigen.2023.102867

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cardiovascular diseases are the most common causes of death worldwide. Cardiac death can occur as reaction to myocardial infarction (MI). A diagnostic challenge arises for sudden unexpected death (SUD) cases with structural abnormalities (SA) or without any structural abnormalities (without SA). Therefore, the identification of reliable biomarkers to differentiate cardiac cases from each other is necessary. In the current study, the potential of different microRNAs (miRNAs) as biomarkers in tissue and blood samples of cardiac death cases was analyzed. Blood and tissue samples of 24 MI, 21 SUD and 5 control (C) cases were collected during autopsy. Testing for significance and receiver operating characteristic analysis (ROC) were performed. The results show that miR-1, miR-133a and miR-26a possess a high diagnostic power to discriminate between different cardiac death causes in whole blood and in tissue.

引用

页数：7