Multiple forms of cell death: A focus on the PI3K/AKT pathway

被引:31
作者
Xu, Jiawei [1 ]
Li, Yu [1 ]
Kang, Meili [1 ]
Chang, Cuicui [1 ]
Wei, Hong [2 ]
Zhang, Chi [3 ,4 ,6 ]
Chen, Yuhua [5 ,7 ]
机构
[1] Peihua Univ, Dept Med Sci Res Ctr, Xian, Shaanxi, Peoples R China
[2] Xian Siyuan Univ, Dept Rehabil Teaching & Res, Xian, Peoples R China
[3] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Peoples R China
[4] Inst Skull Base Surg & Neurooncol Hunan Prov, Changsha, Peoples R China
[5] Bijie Tradit Chinese Med Hosp, Dept Neurosurg, Life Sci Res Lab, Bijie, Peoples R China
[6] Cent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410008, Peoples R China
[7] Bijie Tradit Chinese Med Hosp, Dept Neurosurg, Life Sci Res Lab, Bijie 551700, Peoples R China
基金
中国国家自然科学基金;
关键词
cell death; molecular mechanism; PI3K; AKT pathway; regulation; EMERGING MECHANISMS; TUMOR-SUPPRESSOR; LUNG-CANCER; APOPTOSIS; ACTIVATION; AKT; AUTOPHAGY; PROTEIN; FERROPTOSIS; PHOSPHORYLATION;
D O I
10.1002/jcp.31087
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cell death is a natural biological process that occurs in living organisms. Since 1963, extensive research has shed light on the occurrence, progress, and final outcome of cell death. According to different cell phenotypes, it is classified into different types, including apoptosis, pyroptosis, necroptosis, autophagy, ferroptosis, cuproptosis, and so on. However, regardless of the form of cell death, what we ultimately expect is the disappearance of abnormal cells, such as tumor cells, while normal cells survive. As a result, it is vital to investigate the details of cell death, including death triggers, potent regulators, and executioners. Although significant progress has been made in understanding molecular pathways of cell death, many aspects remain unclear because of the complex regulatory networks in cells. Among them, the phosphoinositide-3-kinase (PI3K)/protein kinase B(AKT) pathway is discovered to be a crucial regulator of the cell death process. AKT, as a proto-oncogene, has become a major focus of attention in the medical community due to its role in regulating a multiplicity of cellular functions counting metabolism, immunity, proliferation, survival, transcription, and protein synthesis. Here, we explored the connection between the PI3K/AKT pathway and cell death, aiming to enhance our comprehension of the mechanism underlying this process. Such knowledge may pave the way for the subsequent development of more effective disease treatments, such as finding suitable targets for drug intervention.
引用
收藏
页码:2026 / 2038
页数:13
相关论文
共 115 条
[81]   ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer [J].
Sugiura, Reiko ;
Satoh, Ryosuke ;
Takasaki, Teruaki .
CELLS, 2021, 10 (10)
[82]   Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling [J].
Sugiyama, Michael G. ;
Fairn, Gregory D. ;
Antonescu, Costin N. .
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019, 7
[83]   Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85, androgen receptor, and Src (vol 278, pg 42992, 2003) [J].
Sun, Mei ;
Yang, Lin ;
Feldman, Richard I. ;
Sun, Xia-meng ;
Bhalla, Kapil N. ;
Jove, Richard ;
Nicosia, Santo V. ;
Cheng, Jin Q. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (43) :22841-22841
[84]   FOXO1 and FOXO3a sensitize non-small-cell lung cancer cells to cisplatin-induced apoptosis independent of Bim [J].
Sun, Tianyu ;
Zhang, Jingge ;
Deng, Bo ;
Fan, Xiaoqing ;
Long, Tan ;
Jin, Hua ;
Tao, Shaolin ;
Kang, Poming ;
Tan, Qunyou .
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2020, 52 (12) :1348-1359
[85]  
Sundaram Meera V, 2006, WormBook, P1
[86]   ID1 overexpression increases gefitinib sensitivity in non-small cell lung cancer by activating RIP3/MLKL-dependent necroptosis [J].
Tan, Hor-Yue ;
Wang, Ning ;
Chan, Yau-Tuen ;
Zhang, Cheng ;
Guo, Wei ;
Chen, Feiyu ;
Zhong, Zhangfeng ;
Li, Sha ;
Feng, Yibin .
CANCER LETTERS, 2020, 475 :109-118
[87]   Phosphatidylinositol-3-OH kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4 [J].
Thapa, Narendra ;
Chen, Mo ;
Horn, Hudson T. ;
Choi, Suyong ;
Wen, Tianmu ;
Anderson, Richard A. .
NATURE CELL BIOLOGY, 2020, 22 (11) :1357-+
[88]   Copper induces cell death by targeting lipoylated TCA cycle proteins [J].
Tsvetkov, Peter ;
Coy, Shannon ;
Petrova, Boryana ;
Dreishpoon, Margaret ;
Verma, Ana ;
Abdusamad, Mai ;
Rossen, Jordan ;
Joesch-Cohen, Lena ;
Humeidi, Ranad ;
Spangler, Ryan D. ;
Eaton, John K. ;
Frenkel, Evgeni ;
Kocak, Mustafa ;
Corsello, Steven M. ;
Lutsenko, Svetlana ;
Kanarek, Naama ;
Santagata, Sandro ;
Golub, Todd R. .
SCIENCE, 2022, 375 (6586) :1254-+
[89]   Design, expression, purification and crystallization of human 14-3-3ζ. protein chimera with phosphopeptide from proapoptotic protein BAD [J].
Tugaeva, Kristina, V ;
Remeeva, Alina ;
Gushchin, Ivan ;
Cooley, Richard B. ;
Sluchanko, Nikolai N. .
PROTEIN EXPRESSION AND PURIFICATION, 2020, 175
[90]   At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy [J].
Vasan, Neil ;
Cantley, Lewis C. .
NATURE REVIEWS CLINICAL ONCOLOGY, 2022, 19 (07) :471-485