Pharmacological roles of lncRNAs in diabetic retinopathy with a focus on oxidative stress and inflammation

被引：27

作者：

Chen, Chengming ^{[1
,2
]}

Ding, Peng ^{[3
]}

Yan, Weiming ^{[2
]}

Wang, Zhaoyang ^{[3
]}

Lan, Yanyan ^{[4
]}

Yan, Xiaolong ^{[3
]}

Li, Tian ^{[5
]}

Han, Jing ^{[1
]}

机构：

[1] Air Force Mil Med Univ, Tangdu Hosp, Dept Ophthalmol, 569 Xinsi Rd, Xian 710038, Peoples R China

[2] Xiamen Univ, Hosp Joint Logist Support Force 900, Dept Ophthalmol, PLA Clin Med Coll,Fujian Med Univ,Dongfang Hosp, Fuzhou 350025, Peoples R China

[3] Air Force Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, Xian 710038, Peoples R China

[4] Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou 350122, Peoples R China

[5] Fourth Mil Med Univ, Sch Basic Med, Xian 710032, Peoples R China

来源：

BIOCHEMICAL PHARMACOLOGY | 2023年 / 214卷

基金：

中国国家自然科学基金;

关键词：

Diabetic retinopathy; Long non -coding RNAs; Oxidative stress; Inflammation; LONG NONCODING RNA; GROWTH-FACTOR-BETA; NF-KAPPA-B; HIGH-GLUCOSE; MESENCHYMAL TRANSITION; DOWN-REGULATION; CELLS; APOPTOSIS; ANRIL; MIAT;

D O I：

10.1016/j.bcp.2023.115643

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diabetic retinopathy (DR) is a complication caused by abnormal glucose metabolism, which affects the vision and quality of life of patients and severely impacts the society at large. DR has a complex pathogenic process. Evidence from multiple studies have shown that oxidative stress and inflammation play pivotal roles in DR. Additionally, with the rapid development of various genetic detection methods, the abnormal expression of long non-coding RNAs (lncRNAs) have been confirmed to promote the development of DR. Research has demon-strated the potential of lncRNAs as ideal biomarkers and theranostic targets in DR. In this narrative review, we will focus on the research results on mechanisms underlying DR, list lncRNAs confirmed to be closely related to these mechanisms, and discuss their potential clinical application value and limitations.

引用

页数：13

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