Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery

被引:4
作者
Yang, Yuehan [1 ,2 ]
Kessler, Mara Grace C. [2 ,3 ]
Marchan-Rivadeneira, Maria Raquel [1 ,2 ,4 ,5 ]
Han, Yong [1 ,2 ,6 ]
机构
[1] Ohio Univ, Translat Biomed Sci Program, Athens, OH 45701 USA
[2] Ohio Univ, Edison Biotechnol Inst, Athens, OH 45701 USA
[3] Ohio Univ, Honors Tutorial Coll, Athens, OH 45701 USA
[4] Ohio Univ, Dept Biol Sci, Athens, OH 45701 USA
[5] Pontificia Univ Catolica Ecuador PUCE, Ctr Res Hlth Latinamer CISeAL, Biol Sci Dept, Quito 170143, Ecuador
[6] Ohio Univ, Dept Chem & Biochem, Athens, OH 45701 USA
来源
MOLECULES | 2023年 / 28卷 / 10期
关键词
antimicrobial resistance; genome mining; natural products; antibiotics; biosynthesis gene clusters; BIOSYNTHETIC GENE-CLUSTER; NATURAL-PRODUCT; RIMINOPHENAZINE DERIVATIVES; HALOGENATED PHENAZINES; STRUCTURE ELUCIDATION; POLYKETIDE SYNTHASE; MODE; RIFAMPICIN; REVEALS; PEPTIDE;
D O I
10.3390/molecules28104183
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Constantly evolving drug-resistant "superbugs" have caused an urgent demand for novel antimicrobial agents. Natural products and their analogs have been a prolific source of antimicrobial agents, even though a high rediscovery rate and less targeted research has made the field challenging in the pre-genomic era. With recent advancements in technology, natural product research is gaining new life. Genome mining has allowed for more targeted excavation of biosynthetic potential from natural sources that was previously overlooked. Researchers use bioinformatic algorithms to rapidly identify and predict antimicrobial candidates by studying the genome before even entering the lab. In addition, synthetic biology and advanced analytical instruments enable the accelerated identification of novel antibiotics with distinct structures. Here, we reviewed the literature for noteworthy examples of novel antimicrobial agents discovered through various methodologies, highlighting the candidates with potent effectiveness against antimicrobial-resistant pathogens.
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页数:26
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