Dendritic cell-targeting polymer nanoparticle-based immunotherapy for cancer: A review

被引：6

作者：

Hu, Yeye ^{[1
,4
]}

Zhang, Wei ^{[2
]}

Chu, Xiaozhong ^{[3
]}

Wang, Aoran ^{[3
]}

He, Ziliang ^{[2
]}

Si, Chuan-Ling ^{[4
]}

Hu, Weicheng ^{[1
,5
,6
]}

机构：

[1] Yangzhou Univ, Inst Translat Med, Sch Med, Yangzhou 225009, Peoples R China

[2] Huaiyin Normal Univ, Sch Life Sci, Huaian 223300, Peoples R China

[3] Huaiyin Normal Univ, Sch Chem & Chem Engn, Huaian 223300, Peoples R China

[4] Tianjin Univ Sci & Technol, Tianjin Key Lab Pulp & Paper, Tianjin 300457, Peoples R China

[5] Yangzhou Univ, Affiliated Hosp, Yangzhou 225009, Peoples R China

[6] Yangzhou Univ, Sch Med, Jiangsu Key Lab Expt & Translat Noncoding RNA Res, Yangzhou 225009, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2023年 / 635卷

关键词：

Dendritic cell; Polymer; Target; Receptor; Immunity; POLY(GAMMA-GLUTAMIC ACID) NANOPARTICLES; ANTITUMOR IMMUNE-RESPONSES; DC-SIGN; ANTIGEN PRESENTATION; CROSS-PRESENTATION; LIPID NANOPARTICLES; RECEPTOR ENGAGEMENT; EFFICIENT DELIVERY; VACCINE DELIVERY; FC-RECEPTOR;

D O I：

10.1016/j.ijpharm.2023.122703

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cancer immunity is dependent on dynamic interactions between T cells and dendritic cells (DCs). Polymer-based nanoparticles target DC receptors to improve anticancer immune responses. In this paper, DC surface receptors and their specific coupling natural ligands and antibodies are reviewed and compared. Moreover, reaction mechanisms are described, and the synergistic effects of immune adjuvants are demonstrated. Also, extracellular-targeting antigen-delivery strategies and intracellular stimulus responses are reviewed to promote the rational design of polymer delivery systems.

引用

页数：21

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