Boron nitride nanocage as drug delivery systems for chloroquine, as an effective drug for treatment of coronavirus disease: A DFT study

被引：7

作者：

Alharthy, Khalid M.

Alsaffar, Marwa Fadhil ^{[1
,2
]}

Althurwi, Hassan N. ^{[1
]}

Albaqami, Faisal F. ^{[1
]}

Abass, Russul Reidh ^{[3
]}

Alawi, Aisha Majid ^{[4
]}

Jalal, Sarah Salah ^{[5
]}

Tabassum, Shazia ^{[6
]}

Zhang, Hao ^{[7
]}

Peng, Wang ^{[7
]}

机构：

[1] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Pharmacol & Toxicol Dept, AlKharj 11942, Saudi Arabia

[2] Al Mustaqbal Univ Coll, Med Labs Tech Dept, Hillah 51001, Babil, Iraq

[3] Al Farahidi Univ, Coll Med Techol, Tech Dept, Med Lab, Baghdad, Iraq

[4] Al Nisour Univ Coll, Tech Dept, Med Lab, Baghdad, Iraq

[5] Natl Univ Sci & Technol, Coll Nursing, Dhi Qar, Iraq

[6] King Khalid Univ, Coll Sci & Arts, Dept English, Rejal Almaa Campus, Abha, Saudi Arabia

[7] Korea Adv Inst Sci & Technol KAIST, Dept Chem, Mol Log Gate Lab, Daejeon, South Korea

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2023年 / 150卷

关键词：

Chloroquine; COVID-19; Nanocage; Delivery; ELECTRONIC RESPONSE; AL; ADSORPTION; ENERGIES;

D O I：

10.1016/j.inoche.2023.110482

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Research has shown that chloroquine (CQ) can effectively help control COVID-19 infection. B24N24 nanocage is a drug delivery system. Thus, through density functional theory, the present study analyzed pristine nanocage-CQ interaction and CQ interaction with Si-and Al-doped nanocage. The findings revealed that nanocage doping, particularly with Si and Al, yields more satisfactory drug delivery for CQ due to their greater electronic and energetic characteristics with CQ.

引用

页数：8

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