Biodegradable Electrospun Scaffolds as an Emerging Tool for Skin Wound Regeneration: A Comprehensive Review

被引:10
作者
Sharma, Deepika [1 ]
Srivastava, Shriyansh [1 ,2 ]
Kumar, Sachin [2 ]
Sharma, Pramod Kumar [1 ]
Hassani, Rym [3 ]
Dailah, Hamad Ghaleb [4 ]
Khalid, Asaad [5 ,6 ]
Mohan, Syam [5 ,7 ,8 ]
机构
[1] Galgotias Univ, Sch Med & Allied Sci, Dept Pharm, Greater Noida 203201, India
[2] Delhi Pharmaceut Sci & Res Univ DPSRU, Dept Pharmacol, Sect 3 Pushp Vihar, New Delhi 110017, India
[3] Jazan Univ, Univ Coll AlDarb, Dept Math, Jazan 45142, Saudi Arabia
[4] Jazan Univ, Coll Nursing, Res & Sci Studies Unit, Jazan 45142, Saudi Arabia
[5] Jazan Univ, Subst Abuse & Toxicol Res Ctr, Jazan 45142, Saudi Arabia
[6] Natl Ctr Res, Med & Aromat Plants & Tradit Med Res Inst, POB 2404, Khartoum, Sudan
[7] Univ Petr & Energy Studies, Sch Hlth Sci, Dehra Dun 248007, India
[8] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Dent Coll, Ctr Transdisciplinary Res,Dept Pharmacol, Chennai 600077, India
关键词
nanofibers; polymers; scaffolds; wound healing; electrospinning; nanoscaffold; biodegradable polymer; NANOFIBROUS SCAFFOLDS; SILVER NANOPARTICLES; MOLECULAR-WEIGHT; CHITOSAN NANOFIBERS; SURFACE-MORPHOLOGY; CELLULOSE-ACETATE; DRUG-DELIVERY; GROWTH-FACTOR; ANTIBACTERIAL; COMPOSITE;
D O I
10.3390/ph16020325
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Skin is designed to protect various tissues, and because it is the largest and first human bodily organ to sustain damage, it has an incredible ability to regenerate. On account of extreme injuries or extensive surface loss, the normal injury recuperating interaction might be inadequate or deficient, bringing about risky and disagreeable circumstances that request the utilization of fixed adjuvants and tissue substitutes. Due to their remarkable biocompatibility, biodegradability, and bioactive abilities, such as antibacterial, immunomodulatory, cell proliferative, and wound mending properties, biodegradable polymers, both synthetic and natural, are experiencing remarkable progress. Furthermore, the ability to convert these polymers into submicrometric filaments has further enhanced their potential (e.g., by means of electrospinning) to impersonate the stringy extracellular grid and permit neo-tissue creation, which is a basic component for delivering a mending milieu. Together with natural biomaterial, synthetic polymers are used to solve stability problems and make scaffolds that can dramatically improve wound healing. Biodegradable polymers, commonly referred to as biopolymers, are increasingly used in other industrial sectors to reduce the environmental impact of material and energy usage as they are fabricated using renewable biological sources. Electrospinning is one of the best ways to fabricate nanofibers and membranes that are very thin and one of the best ways to fabricate continuous nanomaterials with a wide range of biological, chemical, and physical properties. This review paper concludes with a summary of the electrospinning (applied electric field, needle-to-collector distance, and flow rate), solution (solvent, polymer concentration, viscosity, and solution conductivity), and environmental (humidity and temperature) factors that affect the production of nanofibers and the use of bio-based natural and synthetic electrospun scaffolds in wound healing.
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页数:32
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共 147 条
[1]   Electrospun poly(3-hydroxybutyrate-co-3-hydroxy-valerate)/cellulose reinforced nanofibrous membranes with ZnO nanocrystals for antibacterial wound dressings [J].
Abdalkarim, Somia Yassin Hussain ;
Yu, Hou-Yong ;
Wang, Duanchao ;
Yao, Juming .
CELLULOSE, 2017, 24 (07) :2925-2938
[2]   Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages [J].
Abe, Y ;
Hashimoto, S ;
Horie, T .
PHARMACOLOGICAL RESEARCH, 1999, 39 (01) :41-47
[3]   Wound dressing based on electrospun PVA/chitosan/starch nanofibrous mats: Fabrication, antibacterial and cytocompatibility evaluation and in vitro healing assay [J].
Adeli, Hassan ;
Khorasani, Mohammad Taghi ;
Parvazinia, Mahmoud .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 122 :238-254
[4]   Biomimetic PCL-gelatin based nanofibers loaded with ciprofloxacin hydrochloride and quercetin: A potential antibacterial and anti-oxidant dressing material for accelerated healing of a full thickness wound [J].
Ajma, Gufran ;
Bonde, Gunjan Vasant ;
Mittal, Pooja ;
Khan, Gayasuddin ;
Pandey, Vivek Kumar ;
Bakade, Bharati, V ;
Mishra, Brahmeshwar .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 567
[5]   Applications of Electrospun Drug-Eluting Nanofibers in Wound Healing: Current and Future Perspectives [J].
Akombaetwa, Nakamwi ;
Bwanga, Alick ;
Makoni, Pedzisai Anotida ;
Witika, Bwalya A. .
POLYMERS, 2022, 14 (14)
[6]   Reduced Graphene-Oxide-Embedded Polymeric Nanofiber Mats: An "On-Demand" Photothermally Triggered Antibiotic Release Platform [J].
Altinbasak, Ismail ;
Jijie, Roxana ;
Barras, Alexandre ;
Golba, Bianka ;
Sanyal, Rana ;
Bouckaert, Julie ;
Drider, Djamel ;
Bilyy, Rostyslav ;
Dumych, Tetiana ;
Paryzhak, Solomiya ;
Vovk, Volodymyr ;
Boukherroub, Rabah ;
Sanyal, Amitav ;
Szunerits, Sabine .
ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (48) :41098-41106
[7]   Controlled delivery of dexamethasone and betamethasone from PLA electrospun fibers: A comparative study [J].
Alves, Priscila E. ;
Soares, Bluma G. ;
Lins, Luanda C. ;
Livi, Sebastien ;
Santos, Elizabete P. .
EUROPEAN POLYMER JOURNAL, 2019, 117 :1-9
[8]   PHARMACOLOGY OF CURCUMA-LONGA [J].
AMMON, HPT ;
WAHL, MA .
PLANTA MEDICA, 1991, 57 (01) :1-7
[9]   Light-activated nanofibre textiles exert antibacterial effects in the setting of chronic wound healing [J].
Arenbergerova, Monika ;
Arenberger, Petr ;
Bednar, Marek ;
Kubat, Pavel ;
Mosinger, Jiri .
EXPERIMENTAL DERMATOLOGY, 2012, 21 (08) :619-624
[10]   Cerium Oxide Nanoparticle Incorporated Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Membranes for Diabetic Wound Healing Applications [J].
Augustine, Robin ;
Hasan, Anwarul ;
Patan, Noorunnisa Khanam ;
Dalvi, Yogesh B. ;
Varghese, Ruby ;
Antony, Aloy ;
Unni, Raghunath Narayanan ;
Sandhyarani, Neelakandapillai ;
Al Moustafa, Ala-Eddin .
ACS BIOMATERIALS SCIENCE & ENGINEERING, 2020, 6 (01) :58-70