Cu-Catalyzed Polychloromethylamination of Styrenes through C(sp3)-H Bond Cleavage

被引：0

作者：

Zhu, Fengxiang ^{[1
]}

Xue, Jianxin ^{[1
]}

Yin, Pengpeng ^{[1
]}

机构：

[1] Shanxi Univ, Sch Chem & Chem Engn, 92 Wucheng Rd S, Taiyuan 030006, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2023年 / 29卷 / 17期

基金：

中国国家自然科学基金;

关键词：

copper catalyst; multicomponent reaction; polychloromethylamination; radical; styrenes; 3-COMPONENT CARBOAMINATION; ALKENES; AMINO; DIFUNCTIONALIZATION; ALKYNES; ACCESS;

D O I：

10.1002/chem.202203079

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-catalyzed three-component coupling reaction has been developed allowing the rapid building of valuable complex highly functionalized beta-polychloromethyl amines from simple styrenes, arylamines, and dichloromethane/chloroform. Using aryldiazonium salts as a radical initiator, a series of corresponding products are obtained with moderate to good yields under a carbon dioxide or nitrogen atmosphere (50 psi). In addition, good functional group tolerance can be observed.

引用

页数：5

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