The Japan-Multimodal Intervention Trial for Prevention of Dementia PRIME Tamba (J-MINT PRIME Tamba): Study protocol of a randomised controlled multi-domain intervention trial

被引：7

作者：

Kumagai, Ryoko ^{[1
]}

Osaki, Tohmi ^{[2
,3
]}

Oki, Yutaro ^{[2
]}

Murata, Shunsuke ^{[2
,4
]}

Uchida, Kazuaki ^{[5
,6
]}

Encho, Haruhi ^{[5
]}

Ono, Rei ^{[5
,7
]}

Kowa, Hisatomo ^{[1
]}

机构：

[1] Kobe Univ, Dept Rehabil Sci, Div Cognit & Psychiat Rehabil, Grad Sch Hlth Sci,Suma Ku, 7-10-2 Tomogaoka, Kobe, Hyogo 6540142, Japan

[2] Kobe Univ, Ctr Preventing Dementia, Grad Sch Hlth Sci, Suma Ku, 7-10-2 Tomogaoka, Kobe, Hyogo 6540142, Japan

[3] Kobe Gakuin Univ, Fac Rehabil, Dept Occupat Therapy, Nishi Ku, 518 Arise,Ikawadani Cho, Kobe, Hyogo 6512180, Japan

[4] Natl Cerebral & Cardiovasc Ctr Res Inst, Dept Prevent Med & Epidemiol, 6-1 Kishibeshirrunachi, Suita, Osaka 5648565, Japan

[5] Kobe Univ, Dept Publ Hlth, Div Community Hlth Sci, Grad Sch Hlth Sci,Suma Ku, 7-10-2 Tomogaoka, Kobe, Hyogo 6540142, Japan

[6] Natl Ctr Geriatr & Gerontol, Res Inst, Dept Prevent & Care Sci, 7-430 Morioka, Obu, Aichi 4748511, Japan

[7] Natl Inst Hlth & Nutr, Natl Inst Biomed Innovat Hlth & Nutr, Dept Phys Act Res, Shinjyu Ku, 1-23-1 Toyama, Tokyo 1628636, Japan

来源：

ARCHIVES OF GERONTOLOGY AND GERIATRICS | 2023年 / 104卷

关键词：

Cognitive decline; Multi -domain intervention; Vascular risk management; Physical exercise; Cognitive training; Nutritional counselling; COGNITIVE FUNCTION; MENTAL-STATE; OLDER-PEOPLE; VALIDITY; ADULTS; RELIABILITY; DEPRESSION; NETWORK; VERSION; SCALE;

D O I：

10.1016/j.archger.2022.104803

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The Japan-Multimodal Intervention Trial for Prevention of Dementia PRIME Tamba (J-MINT PRIME Tamba) is a randomised controlled trial to prevent cognitive decline in community-dwelling cognitively ordinary older people at risk of dementia. Participants are aged 65-85 years living in a rural area in Japan, aware of very mild decline in cognitive function or abilities of activities of daily living, have at least one vascular risk (e.g. hy-pertension or diabetes), and have a Mini-Mental State Examination score of 24 or higher. Approximately 200 participants are randomly divided into two groups, with the intervention group receiving a multi-modal inter-vention, including lifestyle-related disease management, physical exercise, cognitive training, and nutritional counselling, over 18 months. The primary outcome is change in the composite score of seven neuropsychological tests, including the Free and Cued Selective Reminding Test, Logical Memory I and II subsets of the Wechsler Memory Scale-Revised, and Digit Symbol Substitution Test of the Wechsler Adult Intelligence Scale. In addition, changes in a wide range of other parameters such as physical function, blood test results, sleep, and frailty are also analysed as secondary outcomes. We believe that this study's results will contribute significantly to the development of dementia prevention measures in Japan.Clinical trial registration number: UMIN000041938

引用

页数：8

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