p-TSA Catalyzed One-Pot Synthesis of 2-(1H-Indol-3-yl)-3-Phenylquinazolin-4(3H)-Ones

被引：5
|
作者：
Tamilselvi, Velmurugan [1 ]
Ramesh, Rathinam [2 ]
Lalitha, Appaswami [1 ]
机构：
[1] Periyar Univ, Dept Chem, Salem 636011, Tamil Nadu, India
[2] Sona Coll Arts & Sci, Dept Chem, Salem, Tamil Nadu, India
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2023年 / 43卷 / 01期
关键词：
p-TSA; 2-(1H-indol-3-yl)-3-phenylquinazolin-4(3H)-ones; one-pot; multicomponent; MEDICINAL SCAFFOLDS; DERIVATIVES; QUINAZOLINONE; ANTICANCER; EFFICIENT;
D O I：
10.1080/10406638.2021.2015399
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we wish to report a p-TSA catalyzed synthesis of a new series of 2-(1H-indol-3-yl)-3-phenylquinazolin-4(3H)-ones in methanol at reflux condition. The present protocol has the advantages of simple work up, high yield with shorter reaction time, inexpensive catalyst, easily available starting materials and no need of chromatographic purification. The products were characterized by various spectral techniques.
引用
收藏
页码：434 / 443
页数：10
相关论文
共 50 条
  • [41] Strontium chloride-catalyzed one-pot synthesis of 4(3H)-quinazolinones under solvent-free conditions
    Wang, Min
    Song, Zhi Guo
    Zhang, Ting Ting
    CHINESE CHEMICAL LETTERS, 2010, 21 (10) : 1167 - 1170
  • [42] AMMONIUM CHLORIDE-CATALYZED ONE-POT SYNTHESIS OF 4(3H)-QUINAZOLINONES UNDER SOLVENT-FREE CONDITIONS
    Huang, Guoli
    Liu, Bo
    Teng, Mingyu
    Chen, Yegao
    SYNTHETIC COMMUNICATIONS, 2014, 44 (12) : 1786 - 1794
  • [43] One-Pot Multicomponent Synthesis and Cytotoxic Evaluation of Novel 7-Substituted-5-(1H-Indol-3-yl)Tetrazolo[1,5-a] Pyrimidine-6-Carbonitrile
    Radwan, Mohamed A. A.
    Alminderej, Fahad M.
    Awad, Hanem M.
    MOLECULES, 2020, 25 (02):
  • [44] PPh3/I2-catalyzed one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones
    Zhang, Yanzhi
    Lei, Min
    Xue, Kangsheng
    Sun, Guoxiang
    Zhou, Yang
    Hou, Jinjun
    Long, Huali
    Zhang, Zijia
    Chen, Xubing
    Wu, Wanying
    SYNTHETIC COMMUNICATIONS, 2020, 50 (23) : 3661 - 3668
  • [45] Sulfonated Carbon Catalyzed Biginelli Reaction for One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and -thiones
    Moghaddas, Maryam
    Davoodnia, Abolghasem
    Heravi, Majid M.
    Tavakoli-Hoseini, Niloofar
    CHINESE JOURNAL OF CATALYSIS, 2012, 33 (04) : 706 - 710
  • [46] Synthesis and Antiproliferative Activity of Substituted 3[2-(1H-indol-3-yl)-1,3-thiazol-4-yl]-1H-pyrrolo[3,2-b]pyridines, Marine Alkaloid Nortopsentin Analogues
    Carbone, A.
    Pennati, M.
    Barraja, P.
    Montalbano, A.
    Parrino, B.
    Spano, V.
    Lopergolo, A.
    Sbarra, S.
    Doldi, V.
    Zaffaroni, N.
    Cirrincione, G.
    Diana, P.
    CURRENT MEDICINAL CHEMISTRY, 2014, 21 (14) : 1654 - 1666
  • [47] One-pot synthesis of 1,3,4-oxadiazol-2(3H)-ones with CO2 as a C1 synthon promoted by hypoiodite
    Yang, Na
    Yuan, Gaoqing
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2019, 17 (27) : 6639 - 6644
  • [48] Pd(PPh3)4/AgOAc-catalyzed one-pot synthesis of substituted 3,4-dihydronaphthalen-1(2H)-ones
    Liu, Hui
    Yan, Peiyun
    Li, Yan
    Liu, Jinliang
    Sun, Qian
    Wang, Xingbin
    Wang, Cunde
    MONATSHEFTE FUR CHEMIE, 2012, 143 (07): : 1055 - 1059
  • [49] Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols
    Wang, Ke
    Chen, Hao
    Dai, Xinyan
    Huang, Xupeng
    Feng, Zhiqiang
    RSC ADVANCES, 2021, 11 (22) : 13119 - 13123
  • [50] Lipase Catalyzed One-Pot Synthesis of 3-Methyl-4-(Hetero) Arylmethyleneisoxazole-5(4H)-Ones under Aqueous Conditions
    Kapale, Suraj S.
    Gadkari, Yatin U.
    Chaudhari, Hemchandra K.
    POLYCYCLIC AROMATIC COMPOUNDS, 2023, 43 (06) : 4856 - 4865
12345