Synthesis of 1, 8-dioxodecahydroacridines via Hantzsch condensation using theophylline in an aqueous medium: an eco-friendly and bio-based approach

被引：6

作者：

Dhane, Nilam S. ^{[1
]}

Sapkal, Aboli C. ^{[2
]}

Attar, Suraj R. ^{[2
]}

Dhumal, Sanchita M. ^{[1
]}

Chougule, Ganesh K. ^{[1
]}

Pawar, Samadhan P. ^{[1
]}

Kamble, Santosh B. ^{[2
]}

Gaikwad, Kishor V. ^{[1
]}

机构：

[1] Rajarshi Chhatrapati Shahu Coll, Kolhapur, India

[2] Karmaveer Bhaurao Patil Univ, Yashavantrao Chavan Inst Sci Satara, Lead Coll, Satara, India

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2024年 / 50卷 / 03期

关键词：

Heterocycles; Eco-friendly and bio-based catalyst; 1; 8; Dioxodecahydroacridine; Aqueous medium; ONE-POT SYNTHESIS; HETEROGENEOUS CATALYST; ACRIDINE-DERIVATIVES; GREEN CATALYST; 1,8-DIOXODECAHYDROACRIDINES; EFFICIENT; ACID; HEXAHYDROQUINOLINES; NANOPARTICLES; NANOCATALYST;

D O I：

10.1007/s11164-023-05213-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, we explored the convenient and sustainable method for the synthesis of 1, 8 dioxodecahydroacridine derivatives was achieved via a one-pot condensation reaction of dimedone, para-nitrobenzaldehyde, and ammonium acetate by using theophylline as a catalyst at room temperature in aqueous medium. This environmentally friendly method boasts several notable features, including high product yields, rapid completion of reactions, the use of eco-friendly and bio-based catalysts, straightforward work-up procedures without the need for column chromatography, cost-effectiveness, clean synthesis practices that avoid the use of harmful organic solvents, and exceptional atom efficiency.

引用

收藏

页码：1147 / 1160

页数：14

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