Combined Use of Photobiomodulation and Curcumin-Loaded Iron Oxide Nanoparticles Significantly Improved Wound Healing in Diabetic Rats Compared to Either Treatment Alone

被引:0
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作者
Hekmat, Manouchehr [1 ]
Ahmadi, Houssein [2 ]
Baniasadi, Farazad [3 ]
Ashtari, Behnaz [4 ]
Naserzadeh, Parvaneh [4 ]
Mirzaei, Mansooreh [5 ]
Omidi, Hamidreza [2 ]
Mostafavinia, Atarodalsadat [6 ]
Amini, Abdollah [2 ]
Hamblin, Michael R. [7 ,8 ]
Chien, Sufan [9 ,10 ]
Bayat, Mohammad [2 ,9 ,10 ]
机构
[1] Shahid Beheshti Univ Med Sci, Shahid Modarres Hosp, Dept Paediat Cardiol & Paediat Cardiac Surg, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Dept Biol & Anat Sci, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Sch Nursing & Midwifery, Tehran, Iran
[4] Iran Univ Med Sci, Dept Med Nanotechnol, Fac Adv Technol Med, Tehran, Iran
[5] Mazandaran Univ Med Sci, Fac Med, Dept Anat, Sari, Iran
[6] Islamic Azad Univ, Fac Med, Dept Anat Sci & Cognit Neurosci, Tehran Med Sci, Tehran, Iran
[7] Univ Johannesburg, Fac Hlth Sci, Laser Res Ctr, Doornfontein, South Africa
[8] Iran Univ Med Sci, Radiat Biol Res Ctr, Tehran, Iran
[9] Univ Louisville, Price Inst Surg Res, Louisville, KY 40292 USA
[10] Noveratech LLC, Louisville, KY 40299 USA
关键词
Wound healing; Diabetes mellitus; Photobiomodulation; Low level laser therapy; Magnetic iron oxide nanoparticles; FOOT; THERAPY; OPPORTUNITIES; MANAGEMENT; MELLITUS; CELLS;
D O I
10.34172/jlms.2023.18
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Introduction: Here, we assess the therapeutic effects of photobiomodulation (PBM) and curcumin (CUR)-loaded superparamagnetic iron oxide nanoparticles (SPIONs), alone or together, on the maturation step of a type 1 diabetes (DM1) rat wound model. Methods: Full-thickness wounds were inflicted in 36 rats with diabetes mellitus (DM) induced by the administration of streptozotocin (STZ). The rats were randomly allocated to four groups. Group one was untreated (control); group two received CUR; group 3 received PBM (890 nm, 80 Hz, 0.2 J/cm2); group 4 received a combination of PBM plus CUR. On days 0, 4, 7, and 15, we measured microbial flora, wound closure fraction, tensile strength, and stereological analysis. Results: All treatment groups showed a substantial escalation in the wound closure rate, a substantial reduction in the count of methicillin-resistant Staphylococcus aureus (MRSA), a substantial improvement in wound strength, a substantially improvement in stereological parameters compared to the control group, however, the PBM + CUR group was superior to the other treatment groups (all, P <= 0.05). Conclusion: All treatment groups showed significantly improved wound healing in the DM1 rat model. However, the PBM + CUR group was superior to the other treatment groups and the control group in terms of wound strength and stereological parameters.
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页数:12
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