CAR T Cell Therapy for Post-Transplant Lymphoproliferative Disorder After Solid Organ Transplantation: A Safe and Feasible Therapy for an Orphan Disease

被引：1

作者：

Ibrahim, Uroosa ^{[1
,5
]}

Bassil, Claude ^{[2
]}

Chavez, Julio C. ^{[3
]}

Khimani, Farhad ^{[4
]}

Jain, Michael ^{[4
]}

Locke, Frederick L. ^{[4
]}

Osman, Keren ^{[1
]}

Lazaryan, Aleksandr ^{[4
]}

机构：

[1] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Div Hematol & Oncol, Bone Marrow Transplant & Cellular Therapy, New York, NY 10029 USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Onconephrol, Tampa, FL USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL USA

[4] H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunoth, Tampa, FL USA

[5] Icahn Sch Med Mt Sinai, Tisch Canc Inst, 1 Gustave Levy Pl, New York, NY 10029 USA

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2023年 / 23卷 / 10期

关键词：

Cellular therapy; Diffuse large B cell lymphoma; Liver transplant; Organ rejection; Renal transplant; OUTCOMES;

D O I：

10.1016/j.clml.2023.05.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

• CAR T cell therapy can be a safe an effective treatment option for post-transplant lymphoproliferative disorder. • Careful management of immunosuppressive medications before and during the treatment period is required to prevent graft rejection. • Low dose of immunosuppression during CAR T cell therapy can be maintained and may not affect efficacy. • A multidisciplinary team approach throughout the process is essential. © 2023 Elsevier Inc.

引用

页码：772 / 778

页数：7

共 16 条

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