Lanthanum vanadate-based carbon nanocomposite as an electrochemical probe for amperometric detection of theophylline in real food samples

Theophylline (THP) is an emerging drug for chronic obstructive pulmonary disease whose side effects can be greatly affected by caffeine-containing real foods. Because an overdose of this substance can cause respiratory and neurological damage, producing a fast and accurate analytical procedure is critical. Based on a cutting-edge hybrid nanocomposite, this study was used to construct an electrochemical sensor for the accurate detection of THP. Spectroscopy and morphological investigation supported the easy synthesis of tetragonal-LaVO4 (t-LV) nanopellets and LV@CNF hybrid nanocomposite. To detect THP, a highly dispersed LV@CNF nanocomposite was modified on a glassy carbon electrode as a sensing substrate. By amperometric technique, the sensor shows a wide linear range of 0.01-1070 & mu;M, low limit of detection (2.63 nM), and sensitivity (0.228 & mu;A & mu;M-1 cm-2). Finally, the current technique was successfully used to identify THP in real food samples (chocolate, coffee and black tea).