The Natural History of Hereditary Colorectal Cancer Syndromes: From Phenotype to Genotype? Where Do We Stand and What Does the Future Hold?

被引：0

作者：

Church, James ^{[1
,2
]}

机构：

[1] Columbia Univ, Div Colorectal Surg, Dept Surg, Med Ctr, New York, NY USA

[2] Columbia Univ, Div Colorectal Surg, Dept Surg, Med Ctr, Herbert Irving Pavil,161 Ft Washington Ave,8th Flo, New York, NY 10032 USA

来源：

CLINICS IN COLON AND RECTAL SURGERY | 2024年 / 37卷 / 03期

关键词：

hereditary colorectal cancer; molecular genetics of colorectal cancer; GERMLINE MUTATIONS; SERRATED POLYPOSIS; GENE; COLON; DNA; IDENTIFICATION; DISEASE; RECTUM;

D O I：

10.1055/s-0043-1770380

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Applying the concept of a "natural history" to hereditary colorectal cancer is an interesting exercise because the way the syndromes are approached has changed so drastically. However, the exercise is instructive as it forces us to think in depth about where we are, where we have been, and, most helpfully, about where we may be going. In this article the diagnosis, along with endoscopic and surgical management of hereditary colorectal cancer are discussed in the context of their history and the changes in genomics and technology that have occurred over the last one hundred years.

引用

页码：127 / 132

页数：6

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