Monitoring the SARS-CoV-2 Pandemic: Prevalence of Antibodies in a Large, Repetitive Cross-Sectional Study of Blood Donors in Germany-Results from the SeBluCo Study 2020-2022

被引：6

作者：

Offergeld, Ruth ^{[1
]}

Preussel, Karina ^{[1
]}

Zeiler, Thomas ^{[2
]}

Aurich, Konstanze ^{[3
]}

Baumann-Baretti, Barbara I. ^{[4
]}

Ciesek, Sandra ^{[5
]}

Corman, Victor M. ^{[6
]}

Dienst, Viktoria ^{[4
]}

Drosten, Christian ^{[6
]}

Goerg, Siegfried ^{[7
]}

Greinacher, Andreas ^{[3
]}

Grossegesse, Marica ^{[1
]}

Haller, Sebastian ^{[1
]}

Heuft, Hans-Gert ^{[8
]}

Hofmann, Natalie ^{[1
]}

Horn, Peter A. ^{[9
]}

Houareau, Claudia ^{[1
]}

Guelec, Ilay ^{[10
]}

Klingberg, Carlos Luis Jimenez ^{[2
]}

Juhl, David ^{[7
]}

Lindemann, Monika ^{[9
]}

Martin, Silke ^{[11
]}

Neuhauser, Hannelore K. ^{[1
]}

Nitsche, Andreas ^{[1
]}

Ohme, Julia ^{[12
]}

Peine, Sven ^{[13
]}

Sachs, Ulrich J. ^{[14
]}

Schaade, Lars ^{[1
]}

Schaefer, Richard ^{[15
]}

Scheiblauer, Heinrich ^{[16
]}

Schlaud, Martin ^{[1
]}

Schmidt, Michael ^{[10
]}

Umhau, Markus ^{[15
]}

Vollmer, Tanja ^{[17
]}

Wagner, Franz F. ^{[12
]}

Wieler, Lothar H. ^{[1
]}

Wilking, Hendrik ^{[1
]}

Ziemann, Malte ^{[7
]}

Zimmermann, Marlow ^{[1
]}

an der Heiden, Matthias ^{[1
]}

机构：

[1] Robert Koch Inst, Nordufer 20, D-13353 Berlin, Germany

[2] German Red Cross Blood Serv West, D-58097 Hagen, Germany

[3] Univ Med Greifswald, Inst Immunol & Transfus Med, Sauerbruchstr, D-17475 Greifswald, Germany

[4] Haema AG, Landsteinerstr 1, D-04103 Leipzig, Germany

[5] Goethe Univ Frankfurt Main, Univ Hosp, Inst Med Virol, German Ctr Infect Res,External Partner Site Frankf, D-39120 Frankfurt, Germany

[6] Charite Univ Med Berlin, Inst Virol, German Natl Reference Lab Coronavirus, D-10117 Berlin, Germany

[7] Univ Hosp Schleswig Holstein, Inst Transfus Med, Ratzeburger Allee 160, D-23538 Lubeck, Germany

[8] Univ Hosp Magdeburg, Inst Transfus Med & Immunohaematol Blood Bank, Leipziger Str 44, D-39120 Magdeburg, Germany

[9] Univ Hosp Essen, Inst Transfus Med, Hufelandstr 55, D-45147 Essen, Germany

[10] German Red Cross Blood Transfus Serv Baden Wurttem, Inst Transfus Med & Immunohematol, Sandhofstr 1, D-60528 Frankfurt, Germany

[11] Bavarian Red Cross Blood Serv, Herzog Heinrich Str 2, D-80336 Munich, Germany

[12] German Red Cross Blood Serv NSTOB, Eldagsener Str 38, D-31832 Springe, Germany

[13] Univ Med Ctr Hamburg Eppendorf, Inst Transfus Med, D-20251 Hamburg, Germany

[14] Univ Hosp Giessen & Marburg, Ctr Transfus Med & Haemotherapy, Langhansstr 7, D-35392 Giessen, Germany

[15] Univ Freiburg, Inst Transfus Med & Gene Therapy, Fac Med, Med Ctr, Hugstetter Str 55, D-79106 Freiburg, Germany

[16] Paul Ehrlich Inst, IVD Testing Lab, D-63225 Langen, Germany

[17] Ruhr Univ Bochum, Inst Lab & Transfus Med, Heart & Diabet Ctr NRW, D-32545 Bad Oeynhausen, Germany

来源：

PATHOGENS | 2023年 / 12卷 / 04期

关键词：

SARS-CoV-2; COVID-19; seroprevalence; COVID-19 serological testing; blood donors; surveillance;

D O I：

10.3390/pathogens12040551

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

SARS-CoV-2 serosurveillance is important to adapt infection control measures and estimate the degree of underreporting. Blood donor samples can be used as a proxy for the healthy adult population. In a repeated cross-sectional study from April 2020 to April 2021, September 2021, and April/May 2022, 13 blood establishments collected 134,510 anonymised specimens from blood donors in 28 study regions across Germany. These were tested for antibodies against the SARS-CoV-2 spike protein and nucleocapsid, including neutralising capacity. Seroprevalence was adjusted for test performance and sampling and weighted for demographic differences between the sample and the general population. Seroprevalence estimates were compared to notified COVID-19 cases. The overall adjusted SARS-CoV-2 seroprevalence remained below 2% until December 2020 and increased to 18.1% in April 2021, 89.4% in September 2021, and to 100% in April/May 2022. Neutralising capacity was found in 74% of all positive specimens until April 2021 and in 98% in April/May 2022. Our serosurveillance allowed for repeated estimations of underreporting from the early stage of the pandemic onwards. Underreporting ranged between factors 5.1 and 1.1 in the first two waves of the pandemic and remained well below 2 afterwards, indicating an adequate test strategy and notification system in Germany.

引用

页数：17

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