Anticancer therapeutic potential of benzofuran scaffolds

被引：44
作者：
Abbas, Ashraf A. [1 ]
Dawood, Kamal M. [1 ]
机构：
[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt
来源：
RSC ADVANCES | 2023年 / 13卷 / 16期
基金：
英国科研创新办公室;
关键词：
BIOACTIVE BENZOFURAN; DIHYDROBENZOFURAN LIGNANS; BIOLOGICAL EVALUATION; ANTITUMOR AGENTS; DERIVATIVES; CANCER; DESIGN; INHIBITORS; DISCOVERY; AURONE;
D O I：
10.1039/d3ra01383a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Benzofuran moiety is the main component of many biologically active natural and synthetic heterocycles. These heterocycles have unique therapeutic potentials and are involved in various clinical drugs. The reported results confirmed the extraordinary inhibitory potency of such benzofurans against a panel of human cancer cell lines compared with a wide array of reference anticancer drugs. Several publications about the anticancer potencies of benzofuran-based heterocycles were encountered. The recent developments of anticancer activities of both natural and synthetic benzofuran scaffolds during 2019-2022 are thoroughly covered. Many of the described benzofurans are promising candidates for development as anticancer agents based on their outstanding inhibitory potency against a panel of human cancer cells compared with reference anticancer drugs. These findings encourage medicinal chemists to explore new areas to improve human health and reduce suffering.
引用
收藏
页码：11096 / 11120
页数：25
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  • [31] Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study
    El-Khouly, Omar A.
    Henen, Morkos A.
    El-Sayed, Magda A. -A.
    Shabaan, Mona I.
    El-Messery, Shahenda M.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 31
  • [32] Design, synthesis, biological evaluation, and molecular docking of new benzofuran and indole derivatives as tubulin polymerization inhibitors
    El-Sayed, Naglaa F.
    El-Hussieny, Marwa
    Ewies, Ewies F.
    El Shehry, Mohamed F.
    Awad, Hanem M.
    Fouad, Marwa A.
    [J]. DRUG DEVELOPMENT RESEARCH, 2022, 83 (02) : 485 - 500
  • [33] Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer
    Eldehna, Wagdy M.
    Salem, Rofaida
    Elsayed, Zainab M.
    Al-Warhi, Tarfah
    Knany, Hamada R.
    Ayyad, Rezk R.
    Traiki, Thamer Bin
    Abdulla, Maha-Hamadien
    Ahmad, Rehan
    Abdel-Aziz, Hatem A.
    El-Haggar, Radwan
    [J]. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, 36 (01) : 1424 - 1435
  • [34] Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies
    Eldehna, Wagdy M.
    Al-Rashood, Sara T.
    Al-Warhi, Tarfah
    Eskandrani, Razan O.
    Alharbi, Amal
    El Kerdawy, Ahmed M.
    [J]. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, 36 (01) : 270 - 285
  • [35] Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer
    Eldehna, Wagdy M.
    Nocentini, Alessio
    Elsayed, Zainab M.
    Al-Warhi, Tarfah
    Aljaeed, Nada
    Alotaibi, Ohoud J.
    Alsanea, Mohammad
    Abdel-Aziz, Hatem
    Supuran, Claudiu T.
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2020, 11 (05): : 1022 - 1027
  • [36] Discovery of 4,6-bis(benzyloxy)-3-phenylbenzofuran as a novel Pin1 inhibitor to suppress hepatocellular carcinoma via upregulating microRNA biogenesis
    Fan, Xin
    He, Huaiyu
    Li, Jiao
    Luo, Guoyong
    Zheng, Yuanyuan
    Zhou, Jian-Kang
    He, Juan
    Pu, Wenchen
    Zhao, Yun
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 27 (11) : 2235 - 2244
  • [37] Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular modelling study
    Fares, Salma
    Selim, Khalid B.
    Goda, Fatma E.
    El-Sayed, Magda A. A.
    AlSaif, Nawaf A.
    Hefnawy, Mohamed M.
    Abdel-Aziz, Alaa A. -M.
    El-Azab, Adel S.
    [J]. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, 36 (01) : 1488 - 1499
  • [38] Isolation of dihydrobenzofuran derivatives from ethnomedicinal species Polygonum barbatum as anticancer compounds
    Farooq, Umar
    Naz, Sadia
    Shams, Afshan
    Raza, Yasir
    Ahmed, Ayaz
    Rashid, Umer
    Sadiq, Abdul
    [J]. BIOLOGICAL RESEARCH, 2019, 52 (1)
  • [39] New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors
    Filimonov, Aleksander S.
    Chepanova, Arina A.
    Luzina, Olga A.
    Zakharenko, Alexandra L.
    Zakharova, Olga D.
    Ilina, Ekaterina S.
    Dyrkheeva, Nadezhda S.
    Kuprushkin, Maxim S.
    Kolotaev, Anton, V
    Khachatryan, Derenik S.
    Patel, Jinal
    Leung, Ivanhoe K. H.
    Chand, Raina
    Ayine-Tora, Daniel M.
    Reynisson, Johannes
    Volcho, Konstantin P.
    Salakhutdinov, Nariman F.
    Lavrik, Olga, I
    [J]. MOLECULES, 2019, 24 (20):
  • [40] Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products
    Gao, Bo
    Yang, Bo
    Feng, Xudong
    Li, Chun
    [J]. NATURAL PRODUCT REPORTS, 2022, 39 (01) : 139 - 162
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