Treatment of Alzheimer's disease with small-molecule photosensitizers

被引：14
作者：
Jiang, Yefei
Zeng, Zhiyong [1 ]
Yao, Jianhua [2 ]
Guan, Ying [2 ]
Jia, Peipei [1 ,3 ]
Zhao, Xiaoli [1 ]
Xu, Lin [1 ,3 ]
机构：
[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
[2] Yunnan Acad Tobacco Sci, Joint Inst Tobacco & Hlth, Kunming 650024, Peoples R China
[3] East China Normal Univ, Wuhu Hosp, Peoples Hosp Wuhu 2, Wuhu 241001, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2023年 / 34卷 / 05期
关键词：
Alzheimer?s disease; Photosensitizer; B aggregation; PDT; BETA-AMYLOID AGGREGATION; PHOTODYNAMIC THERAPY; METHYLENE-BLUE; LIGHT; PEPTIDE; CANCER; PHOTODEGRADATION; INHIBITION; PROTEIN; CYTOTOXICITY;
D O I：
10.1016/j.cclet.2022.107966
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Alzheimer's disease is a neurodegenerative disease that signals for excess ,B-amyloid (A ,B) aggregation. Although people have made great attempts to control the aggregation of A ,B, no effective medications have been produced yet. Due to its excellent temporal and spatial selectivity, photodynamic treatment has been gradually employed and interfered in the aggregation process of A ,B, with some achievement. To enhance the research and application of photodynamic therapy in Alzheimer's disease, this paper reviews the progress of small-molecule photosensitizers in the treatment of Alzheimer's disease in recent years and outlines existing tactics and potential obstacles. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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页数：11
相关论文
共 73 条
[61]   Blood-based Alzheimer's disease diagnosis using fluorescent peptide nanoparticle arrays [J].
Sun, Leming ;
Lei, Yang ;
Wang, Yuerong ;
Liu, Dingchang .
CHINESE CHEMICAL LETTERS, 2022, 33 (04) :1946-1950
[62]   Photo-oxygenation inhibits tau amyloid formation [J].
Suzuki, Takanobu ;
Hori, Yukiko ;
Sawazaki, Taka ;
Shimizu, Yusuke ;
Nemoto, Yu ;
Taniguchi, Atsuhiko ;
Ozawa, Shuta ;
Sohma, Youhei ;
Kanai, Motomu ;
Tomita, Taisuke .
CHEMICAL COMMUNICATIONS, 2019, 55 (44) :6165-6168
[63]   Attenuation of the Aggregation and Neurotoxicity of Amyloid-β Peptides by Catalytic Photooxygenation [J].
Taniguchi, Atsuhiko ;
Sasaki, Daisuke ;
Shiohara, Azusa ;
Iwatsubo, Takeshi ;
Tomita, Taisuke ;
Sohma, Youhei ;
Kanai, Motomu .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (05) :1382-1385
[64]   Clearance of Alzheimer's Aβ peptide:: The many roads to perdition [J].
Tanzi, RE ;
Moir, RD ;
Wagner, SL .
NEURON, 2004, 43 (05) :605-608
[65]   Methylene blue in photodynamic therapy: From basic mechanisms to clinical applications [J].
Tardivo, Joao Paulo ;
Del Giglio, Auro ;
de Oliveira, Carla Santos ;
Gabrielli, Dino Santesso ;
Junqueira, Helena Couto ;
Tada, Dayane Batista ;
Severino, Divinomar ;
Turchiello, Rozane de Fatima ;
Baptista, Mauricio S. .
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2005, 2 (03) :175-191
[66]   Alzheimer's disease: Recent treatment strategies [J].
Vaz, Miguel ;
Silvestre, Samuel .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2020, 887
[67]   Dithienylethene metallodendrimers with high photochromic efficiency [J].
Wang, Yuxuan ;
Zhou, Qifeng ;
He, Xiaoxiao ;
Zhang, Ying ;
Tan, Hongwei ;
Xu, Jianhua ;
Wang, Cuihong ;
Wang, Wei ;
Luo, Xiping ;
Chen, Jinquan ;
Xu, Lin .
CHINESE CHEMICAL LETTERS, 2022, 33 (03) :1613-1618
[68]   Tirapazamine encapsulated hyaluronic acid nanomicelles realized targeted and efficient photo-bioreductive cascading cancer therapy [J].
Wu, Chunhui ;
Liu, Qiuyue ;
Wang, Yikun ;
Xie, Zhengxin ;
Huang, Honglin ;
Li, Ningxi ;
Wei, Xiaodan ;
Yang, Geng ;
Li, Tingting ;
Yang, Hong ;
Li, Shun ;
Qin, Xiang ;
Liu, Yiyao .
CHINESE CHEMICAL LETTERS, 2021, 32 (08) :2400-2404
[69]   Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications [J].
Xu, Yuling ;
Li, Chonglu ;
Lu, Shuai ;
Wang, Zhizheng ;
Liu, Shuang ;
Yu, Xiujun ;
Li, Xiaopeng ;
Sun, Yao .
NATURE COMMUNICATIONS, 2022, 13 (01)
[70]   Design of a Metallacycle-Based Supramolecular Photosensitizer for In Vivo Image-Guided Photodynamic Inactivation of Bacteria [J].
Xu, Yuling ;
Tuo, Wei ;
Yang, Liang ;
Sun, Yan ;
Li, Chonglu ;
Chen, Xiaoqiang ;
Yang, Wenchao ;
Yang, Guangfu ;
Stang, Peter J. ;
Sun, Yao .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 61 (05)
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