Treatment of Alzheimer's disease with small-molecule photosensitizers

被引：14

作者：

Jiang, Yefei

Zeng, Zhiyong ^{[1
]}

Yao, Jianhua ^{[2
]}

Guan, Ying ^{[2
]}

Jia, Peipei ^{[1
,3
]}

Zhao, Xiaoli ^{[1
]}

Xu, Lin ^{[1
,3
]}

机构：

[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

[2] Yunnan Acad Tobacco Sci, Joint Inst Tobacco & Hlth, Kunming 650024, Peoples R China

[3] East China Normal Univ, Wuhu Hosp, Peoples Hosp Wuhu 2, Wuhu 241001, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2023年 / 34卷 / 05期

关键词：

Alzheimer?s disease; Photosensitizer; B aggregation; PDT; BETA-AMYLOID AGGREGATION; PHOTODYNAMIC THERAPY; METHYLENE-BLUE; LIGHT; PEPTIDE; CANCER; PHOTODEGRADATION; INHIBITION; PROTEIN; CYTOTOXICITY;

D O I：

10.1016/j.cclet.2022.107966

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alzheimer's disease is a neurodegenerative disease that signals for excess ,B-amyloid (A ,B) aggregation. Although people have made great attempts to control the aggregation of A ,B, no effective medications have been produced yet. Due to its excellent temporal and spatial selectivity, photodynamic treatment has been gradually employed and interfered in the aggregation process of A ,B, with some achievement. To enhance the research and application of photodynamic therapy in Alzheimer's disease, this paper reviews the progress of small-molecule photosensitizers in the treatment of Alzheimer's disease in recent years and outlines existing tactics and potential obstacles. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

引用

页数：11

共 73 条

[1] New photosensitizers for photodynamic therapy [J].

Abrahamse, Heidi ;

Hamblin, Michael R. .

BIOCHEMICAL JOURNAL, 2016, 473 :347-364

[2] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].

BJORKMAN, PJ ;

SAPER, MA ;

SAMRAOUI, B ;

BENNETT, WS ;

STROMINGER, JL ;

WILEY, DC .

NATURE, 1987, 329 (6139) :506-512

[3] Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization [J].

Celli, Jonathan P. ;

Spring, Bryan Q. ;

Rizvi, Imran ;

Evans, Conor L. ;

Samkoe, Kimberley S. ;

Verma, Sarika ;

Pogue, Brian W. ;

Hasan, Tayyaba .

CHEMICAL REVIEWS, 2010, 110 (05) :2795-2838

[4] Self-assembly of amphiphilic peptides to construct activatable nanophotosensitizers for theranostic photodynamic therapy [J].

Chen, Shuang ;

Liu, Yongzhuo ;

Liang, Ri ;

Hong, Gaobo ;

An, Jing ;

Peng, Xiaojun ;

Zheng, Wen-Heng ;

Song, Fengling .

CHINESE CHEMICAL LETTERS, 2021, 32 (12) :3903-3906

[5] Naturally occurring polyphenolic inhibitors of amyloid beta aggregation [J].

Churches, Quentin I. ;

Caine, Joanne ;

Cavanagh, Kate ;

Epa, Vidana Chandana ;

Waddington, Lynne ;

Tranberg, C. Elisabet ;

Meyer, Adam G. ;

Varghese, Jose N. ;

Streltsov, Victor ;

Duggan, Peter J. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (14) :3108-3112

[6] Catalytic photooxidation of 4-methoxybenzyl alcohol with a flavin-zinc(II)-cyclen complex [J].

Cibulka, R ;

Vasold, R ;

König, B .

CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (24) :6223-6231

[7] ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models [J].

Cramer, Paige E. ;

Cirrito, John R. ;

Wesson, Daniel W. ;

Lee, C. Y. Daniel ;

Karlo, J. Colleen ;

Zinn, Adriana E. ;

Casali, Brad T. ;

Restivo, Jessica L. ;

Goebel, Whitney D. ;

James, Michael J. ;

Brunden, Kurt R. ;

Wilson, Donald A. ;

Landreth, Gary E. .

SCIENCE, 2012, 335 (6075) :1503-1506

[8] NIR-II Emissive Ru(II) Metallacycle Assisting Fluorescence Imaging and Cancer Therapy [J].

Fan, Yifan ;

Li, Chonglu ;

Bai, Suya ;

Ma, Xin ;

Yang, Jingfang ;

Guan, Xiaofang ;

Sun, Yao .

SMALL, 2022, 18 (23)

[9] Cancer revoked: oncogenes as therapeutic targets [J].

Felsher, DW .

NATURE REVIEWS CANCER, 2003, 3 (05) :375-380

[10] Light-Induced Charge Separation in Densely Packed Donor Acceptor Coordination Cages [J].

Frank, Marina ;

Ahrens, Jennifer ;

Bejenke, Isabel ;

Krick, Marcel ;

Schwarzer, Dirk ;

Clever, Guido H. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (26) :8279-8287

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