Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes

被引：4

作者：

Fragoso-Bargas, Nicolas ^{[1
,2
]}

Page, Christian M. ^{[3
,4
]}

Joubert, Bonnie R. ^{[5
]}

London, Stephanie J. ^{[6
]}

Lee-Odegard, Sindre ^{[2
]}

Opsahl, Julia O. ^{[2
]}

Sletner, Line ^{[7
]}

Jenum, Anne K. ^{[8
]}

Qvigstad, Elisabeth ^{[1
,2
]}

Prasad, Rashmi B. ^{[9
,10
]}

Moen, Gunn-Helen ^{[2
,11
,12
,13
,14
]}

Birkeland, Kare, I ^{[1
,2
]}

Sommer, Christine ^{[1
]}

机构：

[1] Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, N-0424 Oslo, Norway

[2] Univ Oslo, Inst Clin Med, Fac Med, N-0318 Oslo, Norway

[3] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, N-0403 Oslo, Norway

[4] Univ Oslo, Fac Math & Nat Sci, Dept Math, N-0315 Oslo, Norway

[5] NIEHS, Dept Hlth & Human Serv, Populat Hlth Branch, NIH, Durham, NC 27709 USA

[6] NIEHS, Dept Hlth & Human Serv, Epidemiol Branch, Div Intramural Res,NIH, Res Triangle Pk, NC 27709 USA

[7] Akershus Univ Hosp, Dept Pediat & Adolescents Med, N-1478 Lorenskog, Norway

[8] Univ Oslo, Inst Hlth & Soc, Dept Gen Practice, N-0318 Oslo, Norway

[9] Lund Univ, Ctr Diabet, S-21428 Malmo, Sweden

[10] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki 00014, Finland

[11] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

[12] Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, NTNU, N-7491 Trondheim, Norway

[13] Univ Queensland, Frazer Inst, Woolloongabba, Qld 4102, Australia

[14] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol BS8 1QU, Avon, England

来源：

EPIGENOMICS | 2023年 / 15卷 / 01期

基金：

美国国家卫生研究院; 澳大利亚研究理事会;

关键词：

DNA methylation; epigenetic epidemiology; epigenetics; EPIPREG; EWAS; folate; MoBa; pregnancy; FOOD FREQUENCY QUESTIONNAIRE; DNA METHYLATION; NORWEGIAN MOTHER; CHILD COHORT; FOLIC-ACID; SUPPLEMENTATION; PREGNANCY; RISK; POPULATION; METABOLISM;

D O I：

10.2217/epi-2022-0427

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. Results & conclusion: cg19888088 (cross-ancestry) in EBF3, cg01952260 (Europeans) and cg07077240 (South Asians) in HERC3 were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in CASC15. The findings were not replicated and were not significant in cord blood. Tweetable abstractThis research article identified CpG sites associated with serum folate levels in maternal peripheral blood leukocytes. The findings provide new insights about the epigenomic component of serum folate levels.

引用

页码：39 / 52

页数：14

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