Biological Correlates of the Effects of Auricular Point Acupressure on Pain

被引：11

作者：

Yeh, Chao Hsing ^{[1
,7
]}

Lukkahatai, Nada ^{[2
]}

Huang, Xinran ^{[3
]}

Wu, Hulin ^{[3
]}

Wang, Hongyu ^{[1
,4
]}

Zhang, Jingyu ^{[5
]}

Sun, Xinyi ^{[5
]}

Smith, Thomas J. ^{[6
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Cizik Sch Nursing, Houston, TX USA

[2] Johns Hopkins Univ, Sch Nursing, Baltimore, MD USA

[3] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX USA

[4] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Houston, TX USA

[5] Johns Hopkins Univ, Krieger Sch Arts & Sci, Baltimore, MD USA

[6] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[7] 6901 Bertner Ave, Houston, TX 77030 USA

来源：

PAIN MANAGEMENT NURSING | 2023年 / 24卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Auricular point acupressure; Inflammatory biomarkers; Cytokines; Chemokines; Self-management; LOW-BACK-PAIN; CANCER SURVIVORS; ACUPUNCTURE; MANAGEMENT; IL-6; INHIBITOR; CYTOKINES; SOCIETY;

D O I：

10.1016/j.pmn.2022.11.004

中图分类号：

R47 [护理学];

学科分类号：

1011 ;

摘要：

Background: To identify candidate inflammatory biomarkers for the underlying mechanism of auricular point acupressure (APA) on pain relief and examine the correlations among pain intensity, interference, and inflammatory biomarkers.Design: This is a secondary data analysis.Methods: Data on inflammatory biomarkers collected via blood samples and patient self-reported pain intensity and interference from three pilot studies (chronic low back pain, n = 61; arthralgia related to aromatase inhibitors, n = 20; and chemotherapy-induced neuropathy, n = 15) were integrated and analyzed. This paper reports the results based on within-subject treatment effects (change in scores from pre-to post-APA intervention) for each study group (chronic low back pain, cancer pain), between-group differences (changes in scores from pre-to post-intervention between targeted-point APA [T-APA] and non-targeted-point APA [NT-APA]), and correlations among pain intensity, interference, and biomarkers. Results: Within-group analysis (the change score from pre-to post-APA) revealed statistically significant changes in three biomarkers: TNF-alpha (cancer pain in the APA group, p = .03), beta-endorphin (back pain in the APA group, p = .04), and IL-2 (back pain in the NT-APA group, p = .002). Based on between-group analysis in patients with chronic low back pain (T-APA vs NT-APA), IL-4 had the largest effect size (0.35), followed by TNF-alpha (0.29). A strong positive monotonic relationship between IL-1 beta and IL-2 was detected.Conclusions: The current findings further support the potential role of inflammatory biomarkers in the analgesic effects of APA. More work is needed to gain a comprehensive understanding of the underlying mechanisms of APA on chronic pain. Because it is simple, inexpensive, and has no negative side effects, APA can be widely disseminated as an alternative to opioids.(c) 2022 The Authors. Published by Elsevier Inc. on behalf of American Society for Pain Management Nursing.This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

引用

页码：19 / 26

页数：8

共 65 条

[1] As Acupressure Decreases Pain, Acupuncture May Improve Some Aspects of Quality of Life for Women with Primary Dysmenorrhea: A Systematic Review with Meta-Analysis [J].