Defects in PINK-PRKN-PARK7/DJ-1-dependent mitophagy and autosomal recessive Parkinson disease

被引:5
|
作者
Imberechts, Dorien [1 ]
Vandenberghe, Wim [1 ,2 ,3 ]
机构
[1] Leuven Brain Inst, Dept Neurosci, Lab Parkinson Res, Leuven, Belgium
[2] Univ Hosp Leuven, Dept Neurol, Leuven, Belgium
[3] Univ Hosp Leuven, Dept Neurol, Herestr 49, B-3000 Leuven, Belgium
关键词
DJ-1; mitochondria; mitophagy; neurons; optineurin; PARK7; parkin; parkinson's disease; PINK1; PRKN;
D O I
10.1080/15548627.2022.2139129
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:1872 / 1873
页数:2
相关论文
共 34 条
  • [21] Case report: Early-onset Parkinson's disease with lower limb spasticity in a new DJ-1/PARK7 patient
    Fujita, Masako
    Nishijima, Haruo
    Katagai, Atsuko
    Suzuki, Chieko
    Hattori, Nobutaka
    Tomiyama, Masahiko
    FRONTIERS IN NEUROSCIENCE, 2024, 18
  • [22] Drug Repurposing for the Discovery of Potential Inhibitors Targeting DJ-1 (PARK7) Against Parkinson's Disease
    Aldakhil, Taibah
    Altharawi, Ali
    CRYSTALS, 2025, 15 (03)
  • [23] DJ-1/PARK7, But Not Its L166P Mutant Linked to Autosomal Recessive Parkinsonism, Modulates the Transcriptional Activity of the Orphan Nuclear Receptor Nurr1 In Vitro and In Vivo
    Lingling Lu
    Shasha Zhao
    Ge Gao
    Xiaohong Sun
    Huanying Zhao
    Hui Yang
    Molecular Neurobiology, 2016, 53 : 7363 - 7374
  • [24] DJ-1/PARK7, But Not Its L166P Mutant Linked to Autosomal Recessive Parkinsonism, Modulates the Transcriptional Activity of the Orphan Nuclear Receptor Nurr1 In Vitro and In Vivo
    Lu, Lingling
    Zhao, Shasha
    Gao, Ge
    Sun, Xiaohong
    Zhao, Huanying
    Yang, Hui
    MOLECULAR NEUROBIOLOGY, 2016, 53 (10) : 7363 - 7374
  • [25] The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage
    Xu, Xiuling
    Martin, Florent
    Friedman, Jeffrey S.
    BLOOD CELLS MOLECULES AND DISEASES, 2010, 45 (03) : 227 - 232
  • [26] Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7)
    Hering, R
    Strauss, KA
    Tao, X
    Bauer, A
    Woitalla, D
    Mietz, EM
    Bauer, P
    Schaible, JB
    Müller, T
    Schöls, L
    Klein, C
    Berg, D
    Meyer, PT
    Schulz, JB
    Wollnik, B
    Tong, L
    Krüger, R
    Riess, O
    HUMAN MUTATION, 2004, 24 (04) : 321 - 329
  • [27] Protection Against Dopaminergic Neurodegeneration in Parkinson's Disease-Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson's Disease-Linked PARK7
    Inden, Masatoshi
    Kitamura, Yoshihisa
    Takahashi, Kazunori
    Takata, Kazuyuki
    Ito, Natsuko
    Niwa, Rina
    Funayama, Risa
    Nishimura, Kaneyasu
    Taniguchi, Takashi
    Honda, Toshio
    Taira, Takahiro
    Ariga, Hiroyoshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 117 (03) : 189 - 203
  • [28] Distribution of DJ-1, Parkinson's disease-related protein PARK7, and its alteration in 6-hydroxydopamine-treated hemiparkinsonian rat brain
    Yanagida, Takashi
    Takata, Kazuyuki
    Inden, Masatoshi
    Kitamura, Yoshihisa
    Taniguchi, Takashi
    Yoshimoto, Kanji
    Taira, Takahiro
    Ariga, Hiroyoshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, 102 (02) : 243 - 247
  • [29] Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson's disease-associated DJ-1/PARK 7 missense mutants
    Sanchez-Lanzas, Raul
    Castano, Jose G.
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [30] Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology
    El Manaa, Wejdane
    Duplan, Eric
    Goiran, Thomas
    Lauritzen, Inger
    Vaillant Beuchot, Loan
    Lacas-Gervais, Sandra
    Morais, Vanessa Alexandra
    You, Han
    Qi, Ling
    Salazar, Mario
    Ozcan, Umut
    Chami, Mounia
    Checler, Frederic
    Alves da Costa, Cristine
    AUTOPHAGY, 2021, 17 (12) : 4363 - 4385