Prediction of pathological complete response to neoadjuvant chemotherapy in patients with breast cancer using a combination of contrast-enhanced ultrasound and dynamic contrast-enhanced magnetic resonance imaging

被引:1
|
作者
Han, Xue [1 ]
Yang, Huajing [1 ]
Jin, Shiyang [2 ]
Sun, Yunfeng [3 ]
Zhang, Hongxia [3 ]
Shan, Ming [2 ]
Cheng, Wen [1 ]
机构
[1] Harbin Med Univ, Canc Hosp, Dept Ultrasound, 150 Japing Rd, Harbin, Heilongjiang, Peoples R China
[2] Harbin Med Univ, Canc Hosp, Dept Breast Surg, Harbin, Heilongjiang, Peoples R China
[3] Harbin Med Univ, Canc Hosp, Imaging Ctr, Harbin, Peoples R China
来源
CANCER MEDICINE | 2023年 / 12卷 / 02期
关键词
contrast-enhanced; dynamic contrast-enhanced MRI; neoadjuvant chemotherapy; ultrasound; ultrasound breast cancer; CLINICAL ONCOLOGY/COLLEGE; AMERICAN SOCIETY; THERAPY; RECOMMENDATIONS; PRESSURE; OUTCOMES; LESIONS; MRI;
D O I
10.1002/cam4.5019
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This study aimed to evaluate the value of dynamic contrast-enhanced ultrasound (CEUS) combined with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in predicting pathological complete response (pCR) in patients with breast cancer receiving neoadjuvant chemotherapy (NAC). Fifty-seven female patients with breast cancer (mean age, 50.46 years; range, 32-66 years) scheduled for NAC were recruited. CEUS and DCE-MRI were performed before and after NAC. Imaging features and their changes were compared with postoperative pathological results. After the clinical differences were balanced using propensity score matching, univariate and multiple logistic regression analyses were used to derive the characteristics independently associated with pCR. Receiver operating characteristic curve analysis was performed to assess diagnostic performance. After six to eight cycles of NAC, 24 (42.1%) patients achieved pCR, while 33 (57.9%) did not. Multivariate analysis showed that enhancement order on CEUS and DCE-MRI before NAC, reduction in diameter and enhancement shape on CEUS, maximum diameter on DCE-MRI, and the type of progressive dynamic contrast enhancement after NAC were independently associated with pCR after NAC. The area under the receiver operating characteristic curve for CEUS+DCE-MRI was 0.911 (95% confidence interval, 0.826-0.997), and the specificity and positive predictive values were 87.0% and 87.5%. CEUS and DCE-MRI have the potential for assessing the pathological response to NAC in patients with breast cancer; their combination showed the best diagnostic performance. CEUS+DCE-MRI has proved beneficial for comprehensive assessment and personalizing treatment strategies for patients with breast cancer.
引用
收藏
页码:1389 / 1398
页数:10
相关论文
共 50 条
  • [41] CONTRAST-ENHANCED ULTRASONOGRAPHY VERSUS CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF MEDIASTINAL TUMORS
    Pan, Juhong
    Chen, Wenwei
    Zhang, Haidong
    Huang, Xingyue
    Huang, Xin
    ULTRASOUND IN MEDICINE AND BIOLOGY, 2021, 47 (02): : 261 - 271
  • [42] Multiparametric dynamic contrast-enhanced ultrasound imaging of prostate cancer
    Wildeboer, Rogier R.
    Postema, Arnoud W.
    Demi, Libertario
    Kuenen, Maarten P. J.
    Wijkstra, Hessel
    Mischi, Massimo
    EUROPEAN RADIOLOGY, 2017, 27 (08) : 3226 - 3234
  • [43] Integrating clinicopathologic information and dynamic contrast-enhanced MRI for augmented prediction of neoadjuvant chemotherapy response in breast cancer
    Liu, Tianyu
    Wang, Hong
    Feng, Feiyan
    Li, Wei
    Zheng, Fulin
    Wu, Kai
    Yu, Shengpeng
    Sun, Yanshen
    BIOMEDICAL SIGNAL PROCESSING AND CONTROL, 2025, 103
  • [44] Dynamic Contrast-enhanced Breast MRI for Evaluating Residual Tumor Size after Neoadjuvant Chemotherapy
    Kim, Soo-Yeon
    Cho, Nariya
    Park, In-Ac
    Kwon, Bo Ra
    Shin, Sung Ui
    Kim, Soo Yeon
    Lee, Su Hyun
    Chang, Jung Min
    Moon, Woo Kyung
    RADIOLOGY, 2018, 289 (02) : 327 - 334
  • [45] Contrast-Enhanced Ultrasound Fundamentals: The Pharmacodynamics and Pharmacokinetics of Contrast. Basics of Contrast-Enhanced Ultrasound Imaging
    Fontanilla Echeveste, M. T.
    Ripolles Gonzalez, T.
    Aguirre Pascual, E.
    RADIOLOGIA, 2024, 66 : S36 - S50
  • [46] Dynamic Contrast-Enhanced Magnetic Resonance Imaging in the Assessment of Inflammatory Breast Cancer Prior to and After Neoadjuvant Treatment
    van Uden, Dominique J. P.
    de Wilt, J. Hans W.
    Meeuwis, Carla
    Blanken-Peeters, Charlotte F. J. M.
    Mann, Ritse M.
    BREAST CARE, 2017, 12 (04) : 224 - 229
  • [47] Head-to-head comparison of contrast-enhanced mammography and contrast-enhanced MRI for assessing pathological complete response to neoadjuvant therapy in patients with breast cancer: a meta-analysis
    Min, Kaiyin
    Tong, Lingling
    Tang, Leilei
    Li, Wenjia
    Ji, Bin
    BREAST CANCER RESEARCH AND TREATMENT, 2023, 202 (01) : 1 - 9
  • [48] Head-to-head comparison of contrast-enhanced mammography and contrast-enhanced MRI for assessing pathological complete response to neoadjuvant therapy in patients with breast cancer: a meta-analysis
    Min Kaiyin
    Tong Lingling
    Tang Leilei
    Li Wenjia
    Ji Bin
    Breast Cancer Research and Treatment, 2023, 202 : 1 - 9
  • [49] Contrast-enhanced mammography predicts pathological response after neoadjuvant chemotherapy in locally advanced breast cancer
    Canteros, Daniel
    Walbaum, Benjamin
    Cordova-Delgado, Miguel
    Torrealba, Andres
    Reyes, Constanza
    Elena Navarro, Maria
    Razmilic, Dravna
    Camus, Mauricio
    Dominguez, Francisco
    Navarrete, Orieta
    Pinto, Mauricio P.
    Pizarro, Gonzalo
    Acevedo, Francisco
    Sanchez, Cesar
    ECANCERMEDICALSCIENCE, 2022, 16
  • [50] The kinetic parameters of dynamic contrast-enhanced MRI with ultrafast imaging in breast cancer patients receiving neoadjuvant chemotherapy: Prediction of pathologic complete response and correlation with histologic microvessel density
    Choi, Sung-Eun
    Park, Ah Young
    Kim, Gwang Il
    Jung, Hae Kyoung
    Ko, Kyung Hee
    Kim, Yunju
    MEDICINE, 2025, 104 (05)