Veliparib-Induced Toxicity in Cancer Patients: A Systematic Review and Meta-Analysis

被引：0

作者：

Wang, Peirong ^{[1
]}

Zhao, Ruizhen ^{[1
]}

Jin, Xiaohui ^{[2
]}

Zhou, Xianhua ^{[1
]}

Xie, Xiaolong ^{[3
]}

机构：

[1] Chinese Tradit Med Hosp Meishan, Internal Med Tradit Chinese Med, Meishan, Peoples R China

[2] Chinese Tradit Med Hosp Meishan, Dept Neurol, Meishan, Peoples R China

[3] Chinese Tradit Med Hosp Meishan, Bone injury Tradit Chinese Med, Meishan, Sichuan, Peoples R China

来源：

CANCER INVESTIGATION | 2024年 / 42卷 / 03期

关键词：

Veliparib; adverse events; cancer; meta-analysis; systematic review; LAPAROSCOPIC RADICAL PROSTATECTOMY; URINARY-INCONTINENCE;

D O I：

10.1080/07357907.2024.2338128

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study, we investigate the veliparib-induced toxicity in cancer patients. Databases were searched for RCTs treated with veliparib. We found veliparib could increase the risk of hematologic and gastrointestinal toxicities. Anemia, neutropenia, thrombocytopenia, and nausea were the most common toxicities. Patients diagnosed with gastrointestinal tumors tend to have a higher risk of high-grade neutropenia; patients in the first-line setting tend to have a higher risk of high-grade anemia and neutropenia than those in the >= second line setting. Patients receiving higher dosage of veliparib tend to have a higher risk of all-grade anemia. Veliparib could also increase the risk of insomnia, myalgia, pneumonia, dyspnea, hyponatremia, and fatigue.

引用

页码：260 / 273

页数：14

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