Progress towards the synthesis of shagene A via ring-closing metathesis cascade

被引：1
|
作者：
Bai, Mengmeng [2 ]
Wang, Xinyu [1 ,2 ]
Li, Qi [1 ,2 ]
机构：
[1] Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Small Mol Drug Res Ctr, Shanghai 201203, Peoples R China
来源：
TETRAHEDRON | 2024年 / 154卷
基金：
中国国家自然科学基金;
关键词：
Shagene A and B; Antileishimanial agent; Ring -closing metathesis cascade; Cyclopropanation; SECONDARY ALCOHOLS; CYCLOPROPANATION; CONSTRUCTION; DIENYNES;
D O I：
10.1016/j.tet.2024.133846
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We describe a progress towards the total synthesis of sesquiterpenoid, shagene A, featuring ring -closing metathesis cascade of dienyne to construct the 6/5 bicyclic system, followed by the synthesis of the key intermediate diazoacetate, which could be hypothetically elaborated to the 6/5/3 ring system of natural product shagene A.
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页数：8
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