Key Contributions by the Swiss Tropical and Public Health Institute Towards New and Better Drugs for Tropical Diseases

被引:2
|
作者
Maser, Pascal [1 ,2 ]
Bernhard, Sonja [1 ,2 ]
Brun, Reto [1 ,2 ]
Burri, Christian [1 ,2 ]
Gagneux, Sebastien [1 ,2 ]
Hetzel, Manuel W. [1 ,2 ]
Kaiser, Marcel [1 ,2 ]
Lengeler, Christian [1 ,2 ]
Pluschke, Gerd [1 ,2 ]
Reus, Elisabeth [1 ,2 ]
Rottmann, Matthias [1 ,2 ]
Utzinger, Juerg [1 ,2 ]
Warryn, Louisa [1 ,2 ]
Wittlin, Sergio [1 ,2 ]
Keiser, Jennifer [1 ,2 ]
机构
[1] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, CH-4123 Allschwil, Switzerland
[2] Univ Basel, CH-4001 Basel, Switzerland
基金
英国惠康基金;
关键词
Drug research and development; Infectious diseases of poverty; Neglected tropical diseases; Product development partnership; Swiss TPH; TRYPANOSOMA-BRUCEI-GAMBIENSE; PRESCHOOL-AGED CHILDREN; BLOOD-STREAM FORMS; SCHISTOSOMA-MANSONI; PLASMODIUM-FALCIPARUM; ANTIMALARIAL-DRUG; OPEN-LABEL; IN-VITRO; QINGHAOSU ARTEMISININ; TRICHURIS-TRICHIURA;
D O I
10.2533/chimia.2023.593
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Thanks to its expertise in clinical research, epidemiology, infectious diseases, microbiology, parasitology, public health, translational research and tropical medicine, coupled with deeply rooted partnerships with institutions in low- and middle-income countries (LMICs), the Swiss Tropical and Public Health Institute (Swiss TPH) has been a key contributor in many drug research and development consortia involving academia, pharma and product development partnerships. Our know-how of the maintenance of parasites and their life-cycles in the laboratory, plus our strong ties to research centres and disease control programme managers in LMICs with access to field sites and laboratories, have enabled systems for drug efficacy testing in vitro and in vivo, clinical research, and modelling to support the experimental approaches. Thus, Swiss TPH has made fundamental contributions towards the development of new drugs - and the better use of old drugs - for neglected tropical diseases and infectious diseases of poverty, such as Buruli ulcer, Chagas disease, food-borne trematodiasis (e.g. clonorchiasis, fascioliasis and opisthorchiasis), human African trypanosomiasis, leishmaniasis, malaria, schistosomiasis, soil-transmitted helminthiasis and tuberculosis. In this article, we showcase the success stories of molecules to which Swiss TPH has made a substantial contribution regarding their use as anti-infective compounds with the ultimate aim to improve people's health and well-being.
引用
收藏
页码:593 / 606
页数:14
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