Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study

被引：0

作者：

Franks, Katherine H. ^{[1
]}

Cribb, Lachlan ^{[1
]}

Bransby, Lisa ^{[1
]}

Buckley, Rachel ^{[2
,3
,4
,5
]}

Yassi, Nawaf ^{[6
,7
]}

Chong, Trevor T. -J. ^{[1
,8
,9
]}

Lim, Yen Ying ^{[1
]}

Pase, Matthew P. ^{[1
,10
]}

机构：

[1] Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia

[2] Univ Melbourne, Melbourne Sch Psychol Sci, Parkville, Vic, Australia

[3] Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA

[4] Harvard Med Sch, Boston, MA 02115 USA

[5] Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, Boston, MA USA

[6] Univ Melbourne, Royal Melbourne Hosp, Melbourne Brain Ctr, Dept Med & Neurol, Parkville, Vic, Australia

[7] Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia

[8] Alfred Hlth, Dept Neurol, Melbourne, Vic, Australia

[9] St Vincents Hosp, Dept Clin Neurosci, Melbourne, Vic, Australia

[10] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE REPORTS | 2023年 / 7卷 / 01期

基金：

英国医学研究理事会; 澳大利亚研究理事会; 美国国家卫生研究院;

关键词：

Alzheimer's disease; amyloid; biomarkers; dementia; psychological stress; DISTRESS; RISK; MICE; DEPOSITION; MEMORY; BRAIN;

D O I：

10.3233/ADR-230052

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58 +/- 7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-beta(42), phosphorylated tau-181, total tau, or neurofilament light chain. Cohen's f(2) effect sizes were small in magnitude (f(2) <= 0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.

引用

页码：1025 / 1031

页数：7

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