Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study

被引：0
作者：
Franks, Katherine H. [1 ]
Cribb, Lachlan [1 ]
Bransby, Lisa [1 ]
Buckley, Rachel [2 ,3 ,4 ,5 ]
Yassi, Nawaf [6 ,7 ]
Chong, Trevor T. -J. [1 ,8 ,9 ]
Lim, Yen Ying [1 ]
Pase, Matthew P. [1 ,10 ]
机构：
[1] Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia
[2] Univ Melbourne, Melbourne Sch Psychol Sci, Parkville, Vic, Australia
[3] Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA
[4] Harvard Med Sch, Boston, MA 02115 USA
[5] Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, Boston, MA USA
[6] Univ Melbourne, Royal Melbourne Hosp, Melbourne Brain Ctr, Dept Med & Neurol, Parkville, Vic, Australia
[7] Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia
[8] Alfred Hlth, Dept Neurol, Melbourne, Vic, Australia
[9] St Vincents Hosp, Dept Clin Neurosci, Melbourne, Vic, Australia
[10] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA
来源：
JOURNAL OF ALZHEIMERS DISEASE REPORTS | 2023年 / 7卷 / 01期
基金：
澳大利亚研究理事会; 英国医学研究理事会; 美国国家卫生研究院;
关键词：
Alzheimer's disease; amyloid; biomarkers; dementia; psychological stress; DISTRESS; RISK; MICE; DEPOSITION; MEMORY; BRAIN;
D O I：
10.3233/ADR-230052
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58 +/- 7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-beta(42), phosphorylated tau-181, total tau, or neurofilament light chain. Cohen's f(2) effect sizes were small in magnitude (f(2) <= 0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.
引用
收藏
页码：1025 / 1031
页数：7
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