Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study

被引：0

作者：

Franks, Katherine H. ^{[1
]}

Cribb, Lachlan ^{[1
]}

Bransby, Lisa ^{[1
]}

Buckley, Rachel ^{[2
,3
,4
,5
]}

Yassi, Nawaf ^{[6
,7
]}

Chong, Trevor T. -J. ^{[1
,8
,9
]}

Lim, Yen Ying ^{[1
]}

Pase, Matthew P. ^{[1
,10
]}

机构：

[1] Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia

[2] Univ Melbourne, Melbourne Sch Psychol Sci, Parkville, Vic, Australia

[3] Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA

[4] Harvard Med Sch, Boston, MA 02115 USA

[5] Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, Boston, MA USA

[6] Univ Melbourne, Royal Melbourne Hosp, Melbourne Brain Ctr, Dept Med & Neurol, Parkville, Vic, Australia

[7] Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia

[8] Alfred Hlth, Dept Neurol, Melbourne, Vic, Australia

[9] St Vincents Hosp, Dept Clin Neurosci, Melbourne, Vic, Australia

[10] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE REPORTS | 2023年 / 7卷 / 01期

基金：

澳大利亚研究理事会; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

Alzheimer's disease; amyloid; biomarkers; dementia; psychological stress; DISTRESS; RISK; MICE; DEPOSITION; MEMORY; BRAIN;

D O I：

10.3233/ADR-230052

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58 +/- 7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-beta(42), phosphorylated tau-181, total tau, or neurofilament light chain. Cohen's f(2) effect sizes were small in magnitude (f(2) <= 0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.

引用

页码：1025 / 1031

页数：7

共 50 条

[1] Association between Adipokines and Biomarkers of Alzheimer's Disease: A Cross-Sectional Study
Letra, Liliana
Matafome, Paulo
Rodrigues, Tiago
Duro, Diana
Lemos, Raquel
Baldeiras, Ines
Patricio, Miguel
Castelo-Branco, Miguel
Caetano, Gina
Seica, Raquel
Santana, Isabel
JOURNAL OF ALZHEIMERS DISEASE, 2019, 67 (02) : 725 - 735
[2] Associations between self-reported sleep quality and cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease
Duraes, J.
Marques, P.
Novo, A. M.
Facas, J.
Duro, D.
Lima, M.
Leitao, M. J.
Tabuas-Pereira, M.
Baldeiras, I.
Santana, I.
REVUE NEUROLOGIQUE, 2023, 179 (08) : 877 - 881
[3] The Effect of APOE ε4 on Alzheimer's Disease Fluid Biomarkers: A Cross-Sectional Study Based on the COAST
Zhao, Bote
Zang, Peixi
Quan, Meina
Wang, Qianqian
Guo, Dongmei
Jia, Jianping
Wang, Wei
CNS NEUROSCIENCE & THERAPEUTICS, 2025, 31 (01)
[4] Association of caffeine consumption with cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease: A BALTAZAR cohort study
Blum, David
Cailliau, Emeline
Behal, Helene
Vidal, Jean-Sebastien
Delaby, Constance
Buee, Luc
Allinquant, Bernadette
Gabelle, Audrey
Bombois, Stephanie
Lehmann, Sylvain
Schraen-Maschke, Susanna
Hanon, Olivier
ALZHEIMERS & DEMENTIA, 2024, 20 (10) : 6948 - 6959
[5] Midlife Stress in Relation to Late-Life Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: A 25-Year Follow-Up Study
Johansson, Lena
Kern, Silke
Zetterberg, Henrik
Blennow, Kaj
Borjesson-Hansson, Anne
Rosengren, Lars
Guo, Xinxin
Skoog, Ingmar
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2018, 46 (1-2) : 90 - 99
[6] Relationship Between General Cognition, Visual Assessed Cortical Atrophy, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: A Cross-Sectional Study from a Chinese PUMCH Cohort
Mao, Chenhui
Sha, Longze
Li, Jie
Huang, Xinying
Chu, Shanshan
Lei, Dan
Wang, Jie
Dong, Liling
Liu, Caiyan
Xu, Qi
Peng, Bin
Gao, Jing
JOURNAL OF ALZHEIMERS DISEASE, 2021, 82 (01) : 205 - 214
[7] Association between Life's Simple 7 and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study
Zhao, Yong-Li
Ou, Ya-Nan
Ma, Ya-Hui
Huang, Yu-Yuan
Bi, Yan-Lin
Tan, Lan
Yu, Jin-Tai
ALZHEIMERS RESEARCH & THERAPY, 2022, 14 (01)
[8] Association between self-reported alcohol consumption and diastolic dysfunction: a cross-sectional study
Daka, Bledar
Bennet, Louise
Rastam, Lennart
Hellgren, Margareta, I
Li, Ying
Magnusson, Martin
Lindblad, Ulf
BMJ OPEN, 2023, 13 (10):
[9] Alzheimer's Disease Diagnosis: Discrepancy between Clinical, Neuroimaging, and Cerebrospinal Fluid Biomarkers Criteria in an Italian cohort of Geriatric Outputs: A Retrospective Cross-sectional Study
Dolci, Giulia A. M.
Damanti, Sarah
Scortichini, Valeria
Galli, Alessandro
Rossi, Paolo D.
Abbate, Carlo
Arosio, Beatrice
Mari, Daniela
Arighi, Andrea
Fumagalli, Giorgio G.
Scarpini, Elio
Inglese, Silvia
Marcucci, Maura
FRONTIERS IN MEDICINE, 2017, 4
[10] Unravelling the Association Between Amyloid-PET and Cerebrospinal Fluid Biomarkers in the Alzheimer's Disease Spectrum: Who Really Deserves an A plus ?
Sacchi, Luca
Carandini, Tiziana
Fumagalli, Giorgio Giulio
Pietroboni, Anna Margherita
Contarino, Valeria Elisa
Siggillino, Silvia
Arcaro, Marina
Fenoglio, Chiara
Zito, Felicia
Marotta, Giorgio
Castellani, Massimo
Triulzi, Fabio
Galimberti, Daniela
Scarpini, Elio
Arighi, Andrea
JOURNAL OF ALZHEIMERS DISEASE, 2022, 85 (03) : 1009 - 1020

← 1 2 3 4 5 →