Analytical Method Development and Validation of Quetiapine Fumarate in API and Dosage form by Using RP-HPLC

被引：0

作者：

Lingareddygari, Siva Sanker Reddy ^{[1
]}

Ravikrindhi, Nageswara Rao ^{[1
]}

Nookala, Madana Gopal ^{[1
]}

Muneer, Shaik ^{[1
]}

Nakka, Prasad ^{[1
]}

机构：

[1] Santhiram Coll Pharm, Dept Pharmaceut Anal, Nandyal 518501, Andhra Pradesh, India

来源：

ORIENTAL JOURNAL OF CHEMISTRY | 2023年 / 39卷 / 04期

关键词：

RP-HPLC; Quetiapine fumarate; Acetonitrile; 0.1% Orthophoshoric acid; Validation;

D O I：

10.13005/ojc/390430

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RP-HPLC method developed is a simple, precise and functional technique for the calculation of amount of Quetiapine fumarate from marketed tablets and bulk form. The RP-HPLC analysis was carried out on Hyper chrome ODS-BP 5 mu m column (4.6mmx200mm) using a mobile phase 0.1% Orthophoshoric acid and Acetonitrile (80:20v/v) with pH 5.5. Quetiapine fumarate quantified by using UV detector at 210nm. The retention time of the Quetiapine fumarate was found to be 2.6 minute. The linearity of the drug concentration ranges from 20-400 mu g/mL. The detection and quantification limits were intended at 3.70 mu g/mL and 12.35 mu g/mL. The precision, accuracy, specificity, robustness and degradation studies were validated.

引用

页码：1040 / 1045

页数：6

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