Post-transcriptional regulation of erythropoiesis

被引：8

作者：

Li, Yanan ^{[1
,2
]}

Zhang, Haihang ^{[1
]}

Hu, Bin ^{[1
]}

Wang, Pan ^{[1
]}

Wang, Wei ^{[2
]}

Liu, Jing ^{[1
]}

机构：

[1] Cent South Univ, Mol Biol Res Ctr, Sch Life Sci, Hunan Prov Key Lab Basic & Appl Hematol, Changsha 410078, Hunan, Peoples R China

[2] Cent South Univ, Third Xiangya Hosp, Dept Imaging & Intervent Radiol, Changsha, Hunan, Peoples R China

来源：

BLOOD SCIENCE | 2023年 / 5卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Erythropoiesis; mRNA stability; Noncoding RNA; Post-transcriptional regulation; INHIBITS ERYTHROID-DIFFERENTIATION; INTRON RETENTION PROGRAM; MESSENGER-RNA; SRSF2; MUTATIONS; GENE-EXPRESSION; OVEREXPRESSION; ANEMIA; MEGAKARYOCYTE; MICRORNA-451; PSEUDOGENES;

D O I：

10.1097/BS9.0000000000000159

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Erythropoiesis is a complex, precise, and lifelong process that is essential for maintaining normal body functions. Its strict regulation is necessary to prevent a variety of blood diseases. Normal erythropoiesis is precisely regulated by an intricate network that involves transcription levels, signal transduction, and various epigenetic modifications. In recent years, research on post-transcriptional levels in erythropoiesis has expanded significantly. The dynamic regulation of splicing transitions is responsible for changes in protein isoform expression that add new functions beneficial for erythropoiesis. RNA-binding proteins adapt the translation of transcripts to the protein requirements of the cell, yielding mRNA with dynamic translation efficiency. Noncoding RNAs, such as microRNAs and lncRNAs, are indispensable for changing the translational efficiency and/or stability of targeted mRNAs to maintain the normal expression of genes related to erythropoiesis. N6-methyladenosine-dependent regulation of mRNA translation plays an important role in maintaining the expression programs of erythroid-related genes and promoting erythroid lineage determination. This review aims to describe our current understanding of the role of post-transcriptional regulation in erythropoiesis and erythroid-associated diseases, and to shed light on the physiological and pathological implications of the post-transcriptional regulation machinery in erythropoiesis. These may help to further enrich our understanding of the regulatory network of erythropoiesis and provide new strategies for the diagnosis and treatment of erythroid-related diseases.

引用

页码：150 / 159

页数：10

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