Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases

被引：6

作者：

Zhou, Yaqi ^{[1
]}

Zhang, Yaowen ^{[2
]}

Yu, Wei ^{[2
]}

Qin, Yufen ^{[2
]}

He, Heng ^{[2
]}

Dai, Fengxian ^{[2
]}

Wang, Yibo ^{[2
]}

Zhu, Fengqin ^{[2
]}

Zhou, Guangxi ^{[2
]}

机构：

[1] Jining Med Univ, Dept Clin Med, Jining, Shandong, Peoples R China

[2] Jining Med Univ, Affiliated Hosp, Dept Gastroenterol, Jining 272000, Shandong, Peoples R China

来源：

IMMUNITY INFLAMMATION AND DISEASE | 2023年 / 11卷 / 07期

基金：

中国国家自然科学基金;

关键词：

autoimmune disease; chronic inflammation; signaling pathway; spleen tyrosine kinase; T-CELLS; SYK; NEUTROPHILS; INHIBITION; RECEPTOR; PATHOGENESIS; ACTIVATION; BLOCKADE; FIBROSIS;

D O I：

10.1002/iid3.934

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BackgroundThe high prevalence of chronic inflammatory diseases or autoimmune reactions is a major source of concern and affects the quality of life of patients. Chronic inflammatory or autoimmune diseases are associated with many diseases in humans, including asthma, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease and cancer. Splenic tyrosine kinase (SYK) is a non-receptor tyrosine kinase that plays an important role in immune receptor signalling in immune and inflammatory responses. MethodsThis is a review article in which we searched for keywords "splenic tyrosine kinase", "inflammation" and "autoimmune diseases" in published literature such as Pubmed and Web of Science to collect relevant information and then conducted a study focusing on the latest findings on the involvement of SYK in chronic inflammatory or autoimmune diseases. ResultsThis paper reviews the regulation of Fc & gamma;, NF-& kappa;B, B cell and T cell-related signalling pathways by SYK, which contributes to disease progression in chronic inflammatory and autoimmune diseases such as airway fibrosis, inflammatory skin disease and inflammatory bowel disease. ConclusionThis paper shows that SYK plays an important role in chronic inflammatory and autoimmune diseases. syk targets hematological, autoimmune and other inflammatory diseases and therefore, inhibition of SYK expression or blocking its related pathways may provide new ideas for clinical prevention and treatment of inflammatory or autoimmune diseases.

引用

页数：10

共 57 条

[1] Inhibition of tyrosine kinase signaling by tyrphostin AG126 downregulates the IL-21/IL-21R and JAK/STAT pathway in the BTBR mouse model of autism [J].

Ahmad, Sheikh F. ;

Ansari, Mushtaq A. ;

Nadeem, Ahmed ;

Bakheet, Saleh A. ;

Alsanea, Sary ;

Al-Hosaini, Khaled A. ;

Mahmood, Hafiz M. ;

Alzahrani, Mohammad Z. ;

Attia, Sabry M. .

NEUROTOXICOLOGY, 2020, 77 :1-11

[2] Protection by tyrosine kinase inhibitor, tyrphostin AG126, through the suppression of IL-17A, RORγt, and T-bet signaling, in the BTBR mouse model of autism [J].

Ahmad, Sheikh F. ;

Ansari, Mushtaq A. ;

Nadeem, Ahmed ;

Bakheet, Saleh A. ;

Alshammari, Musaad A. ;

Attia, Sabry M. .

BRAIN RESEARCH BULLETIN, 2018, 142 :328-337

[3] The tyrosine kinase inhibitor tyrphostin AG126 reduces activation of inflammatory cells and increases Foxp3+ regulatory T cells during pathogenesis of rheumatoid arthritis [J].

Ahmad, Sheikh Fayaz ;

Ansari, Mushtaq Ahmad ;

Nadeem, Ahmed ;

Zoheir, Khairy M. A. ;

Bakheet, Saleh A. ;

Al-Shabanah, Othman A. ;

Al Rikabi, Ammar Cherkess ;

Attia, Sabry M. .

MOLECULAR IMMUNOLOGY, 2016, 78 :65-78

[4] The sickening consequences of too much SYK signaling [J].

Aksentijevich, Ivona .

NATURE GENETICS, 2021, 53 (04) :432-434

[5] Amelioration of sepsis-induced acute kidney injury through inhibition of inflammatory cytokines and oxidative stress in dendritic cells and neutrophils respectively in mice: Role of spleen tyrosine kinase signaling [J].

Al-Harbi, Naif O. ;

Nadeem, Ahmed ;

Ahmad, Sheikh F. ;

Alanazi, Mohammed M. ;

Aldossari, Abdullah A. ;

Alasmari, Fawaz .

BIOCHIMIE, 2019, 158 :102-110

[6] Spleen Tyrosine Kinase as a Target Therapy for Pseudomonas aeruginosa Infection [J].

Alhazmi, Alaa .

JOURNAL OF INNATE IMMUNITY, 2018, 10 (04) :255-263

[7] Inhibition of spleen tyrosine kinase attenuates psoriasis-like inflammation in mice through blockade of dendritic cell-Th17 inflammation axis [J].

Alzahrani, Khalid S. ;

Nadeem, Ahmed ;

Ahmad, Sheikh F. ;

Al-Harbi, Naif O. ;

Ibrahim, Khalid E. ;

El-Sherbeeny, Ahmad M. ;

Alhoshani, Ali R. ;

Alshammari, Musaad A. ;

Alotaibi, Moureq R. ;

Al-Harbi, Mohammed M. .

BIOMEDICINE & PHARMACOTHERAPY, 2019, 111 :347-358

[8] Immune thrombocytopenia: From pathogenesis to treatment [J].

Audia, S. ;

Mahevas, M. ;

Bonnotte, B. .

REVUE DE MEDECINE INTERNE, 2021, 42 (01) :16-24

[9] Splenic tyrosine kinase (SYK) inhibitors and their possible use in acute myeloid leukemia [J].

Bartaula-Brevik, Sushma ;

Brattas, Marte Karen Lindstad ;

Tvedt, Tor Henrik Anderson ;

Reikvam, Hakon ;

Bruserud, Oystein .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2018, 27 (04) :377-387

[10] The Activating C-type Lectin-like Receptor NKp65 Signals through a Hemi-immunoreceptor Tyrosine-based Activation Motif (hemITAM) and Spleen Tyrosine Kinase (Syk) [J].

Bauer, Bjoern ;

Wotapek, Tanja ;

Zoeller, Tobias ;

Rutkowski, Emilia ;

Steinle, Alexander .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (08) :3213-3223

← 1 2 3 4 5 6 →