Warfarin pharmacogenetics in a black Zimbabwean cohort: an observational prospective study

被引：0

作者：

Hidjo, Marie Madeleine M. ^{[1
,2
]}

Chikwambi, Zedias ^{[1
,2
]}

Ngwende, Gift ^{[3
]}

Matenga, Jonathan A. ^{[3
]}

Masimirembwa, Collen ^{[1
]}

机构：

[1] African Inst Biomed Sci & Technol, Dept Genom Med, 911 Boronia Township, Beatrice, Zimbabwe

[2] Chinhoyi Univ Technol, Dept Biotechnol, Private Bag 7724, Chinhoyi, Zimbabwe

[3] Univ Zimbabwe, Fac Med & Hlth Sci, Harare, Zimbabwe

来源：

PHARMACOGENOMICS | 2023年 / 24卷 / 10期

基金：

美国国家卫生研究院;

关键词：

genetic variation; pharmacogenomics; VKORC1; warfarin; POPULATION; EFFICACY;

D O I：

10.2217/pgs-2023-0089

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: A prospective observational study was conducted to evaluate the feasibility of implementing clinical guidelines for warfarin dosing in black Zimbabwean patients. Methods: CYP2C9*5, CYP2C9*6, CYP2C9*8 and CYP2C9*11 and VKORC1 c. 1639 G>A variations were observed in 62 study patients. Results & Conclusion: Overall, 39/62 (62.90%) participants did not receive a warfarin starting dose as would have been recommended by Clinical Pharmacogenetics Implementation Consortium guidelines. US FDA and Dutch Pharmacogenetics Working Group guidelines are based on CYP2C9*2 and CYP2C9*3 only, hence, unlikely useful in this cohort, where such variants were not detected. Clinical Pharmacogenetics Implementation Consortium guidelines, on the other hand, have a specific recommendation on the African-specific variants CYP2C9*5, CYP2C9*6 and CYP2C9*11, and are hence suitable for implementation in Zimbabwe and would help optimize warfarin doses in patients in the study cohort.

引用

页码：529 / 538

页数：10

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