Warfarin pharmacogenetics in a black Zimbabwean cohort: an observational prospective study

被引：0
作者：
Hidjo, Marie Madeleine M. [1 ,2 ]
Chikwambi, Zedias [1 ,2 ]
Ngwende, Gift [3 ]
Matenga, Jonathan A. [3 ]
Masimirembwa, Collen [1 ]
机构：
[1] African Inst Biomed Sci & Technol, Dept Genom Med, 911 Boronia Township, Beatrice, Zimbabwe
[2] Chinhoyi Univ Technol, Dept Biotechnol, Private Bag 7724, Chinhoyi, Zimbabwe
[3] Univ Zimbabwe, Fac Med & Hlth Sci, Harare, Zimbabwe
来源：
PHARMACOGENOMICS | 2023年 / 24卷 / 10期
基金：
美国国家卫生研究院;
关键词：
genetic variation; pharmacogenomics; VKORC1; warfarin; POPULATION; EFFICACY;
D O I：
10.2217/pgs-2023-0089
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: A prospective observational study was conducted to evaluate the feasibility of implementing clinical guidelines for warfarin dosing in black Zimbabwean patients. Methods: CYP2C9*5, CYP2C9*6, CYP2C9*8 and CYP2C9*11 and VKORC1 c. 1639 G>A variations were observed in 62 study patients. Results & Conclusion: Overall, 39/62 (62.90%) participants did not receive a warfarin starting dose as would have been recommended by Clinical Pharmacogenetics Implementation Consortium guidelines. US FDA and Dutch Pharmacogenetics Working Group guidelines are based on CYP2C9*2 and CYP2C9*3 only, hence, unlikely useful in this cohort, where such variants were not detected. Clinical Pharmacogenetics Implementation Consortium guidelines, on the other hand, have a specific recommendation on the African-specific variants CYP2C9*5, CYP2C9*6 and CYP2C9*11, and are hence suitable for implementation in Zimbabwe and would help optimize warfarin doses in patients in the study cohort.
引用
收藏
页码：529 / 538
页数：10
相关论文
共 29 条
  • [1] Pharmacogenetics Guidelines: Overview and Comparison of the DPWG, CPIC, CPNDS, and RNPGx Guidelines
    Abdullah-Koolmees, Heshu
    van Keulen, Antonius M.
    Nijenhuis, Marga
    Deneer, Vera H. M.
    [J]. FRONTIERS IN PHARMACOLOGY, 2021, 11
  • [2] Optimizing warfarin dosing using deep reinforcement learning
    Anzabi Zadeh, Sadjad
    Street, W. Nick
    Thomas, Barrett W.
    [J]. JOURNAL OF BIOMEDICAL INFORMATICS, 2023, 137
  • [3] Genetic Factors Influencing Warfarin Dose in Black-African Patients: A Systematic Review and Meta-Analysis
    Asiimwe, Innocent G.
    Zhang, Eunice J.
    Osanlou, Rostam
    Krause, Amanda
    Dillon, Chrisly
    Suarez-Kurtz, Guilherme
    Zhang, Honghong
    Perini, Jamila A.
    Renta, Jessicca Y.
    Duconge, Jorge
    Cavallari, Larisa H.
    Marcatto, Leiliane R.
    Beasly, Mark T.
    Perera, Minoli A.
    Limdi, Nita A.
    Santos, Paulo C. J. L.
    Kimmel, Stephen E.
    Lubitz, Steven A.
    Scott, Stuart A.
    Kawai, Vivian K.
    Jorgensen, Andrea L.
    Pirmohamed, Munir
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2020, 107 (06) : 1420 - 1433
  • [4] Dean L, 2012, MED GENETICS SUMMARI, V2, P257
  • [5] Genetic and Non-Genetic Factors Impact on INR Normalization in Preprocedural Warfarin Management
    Eljilany, Islam
    Elarref, Mohamed
    Shallik, Nabil
    Elzouki, Abdel-Naser
    Bader, Loulia
    El-Bardissy, Ahmed
    Abdelsamad, Osama
    Al-Badriyeh, Daoud
    Cavallari, Larisa H.
    Elewa, Hazem
    [J]. PHARMACOGENOMICS & PERSONALIZED MEDICINE, 2021, 14 : 1069 - 1080
  • [6] Warfarin dosing strategies evolution and its progress in the era of precision medicine, a narrative review
    Fahmi, Amr Mohamed
    Elewa, Hazem
    El Jilany, Islam
    [J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACY, 2022, 44 (03) : 599 - 607
  • [7] Fohner AE., 2022, CLIN DECISION SUPPOR, P85
  • [8] An Expiration Date for Pharmacogenetic Test Results and Prescribing Guidance?
    Hernandez-Martinez, Viviana
    Duconge, Jorge
    Ruano, Gualberto
    [J]. JOURNAL OF APPLIED LABORATORY MEDICINE, 2023, 8 (04) : 826 - 830
  • [9] Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update
    Johnson, J. A.
    Caudle, K. E.
    Gong, L.
    Whirl-Carrillo, M.
    Stein, C. M.
    Scott, S. A.
    Lee, M. T.
    Gage, B. F.
    Kimmel, S. E.
    Perera, M. A.
    Anderson, J. L.
    Pirmohamed, M.
    Klein, T. E.
    Limdi, N. A.
    Cavallari, L. H.
    Wadelius, M.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2017, 102 (03) : 397 - 404
  • [10] Using an electronic medical record patient portal for warfarin self-management: Empowering children and parents
    Jones, Sophie
    Hislop, Jodi L.
    Gilmore, Hollie
    Greenway, Anthea
    Hibbard, James
    Monagle, Paul
    Newall, Fiona
    [J]. RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, 2023, 7 (02)
123