Effect of antiretroviral therapy on decreasing arterial stiffness, metabolic profile, vascular and systemic inflammatory cytokines in treatment-naive HIV: A one-year prospective study

被引：6

作者：

Martinez-Ayala, Pedro ^{[1
]}

Alanis-Sanchez, Guillermo Adrian ^{[2
]}

Alvarez-Zavala, Monserrat ^{[3
]}

Sanchez-Reyes, Karina ^{[3
]}

Ruiz-Herrera, Vida Veronica ^{[1
]}

Cabrera-Silva, Rodolfo Ismael ^{[3
]}

Gonzalez-Hernandez, Luz Alicia ^{[1
,3
]}

Ramos-Becerra, Carlos ^{[2
]}

Cardona-Munoz, Ernesto ^{[2
]}

Andrade-Villanueva, Jaime Federico ^{[1
,3
]}

机构：

[1] Univ Guadalajara, Univ Hosp Fray Antonio Alcalde, HIV Unit Dept, Guadalajara, Mexico

[2] Univ Guadalajara, Dept Physiol, Arterial Stiffness Lab, Guadalajara, Mexico

[3] Univ Guadalajara, HIV & Immunodeficiencies Res Inst, Clin Med Dept, CUCS, Guadalajara, Mexico

来源：

PLOS ONE | 2023年 / 18卷 / 03期

关键词：

IMMUNODEFICIENCY-VIRUS-INFECTION; INTERCELLULAR-ADHESION MOLECULE-1; C-REACTIVE PROTEIN; CAROTID ATHEROSCLEROSIS; ENDOTHELIAL DYSFUNCTION; AORTIC STIFFNESS; E-SELECTIN; EXPRESSION; INITIATION; DISEASE;

D O I：

10.1371/journal.pone.0282728

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

IntroductionCardiovascular disease is a major cause of death among people living with HIV (PLH). Non-treated PLH show increased levels of inflammation and biomarkers of vascular activation, and arterial stiffness as a prognostic cardiovascular disease risk factor. We investigated the effect of one year of ART on treatment-naive HIV(+) individuals on arterial stiffness and inflammatory and vascular cytokines. MethodsWe cross-sectionally compared aortic stiffness via tonometry, inflammatory, and vascular serum cytokines on treatment-naive (n = 20) and HIV (-) (n = 9) matched by age, sex, metabolic profile, and Framingham score. We subsequently followed young, treatment-naive individuals after 1-year of ART and compared aortic stiffness, metabolic profile, and inflammatory and vascular serum biomarkers to baseline. Inflammatory biomarkers included: hs-CRP, D-Dimer, SAA, sCD163s, MCP-1, IL-8, IL-18, MRP8/14. Vascular cytokines included: myoglobin, NGAL, MPO, Cystatin C, ICAM-1, VCAM-1, and MMP9. ResultsTreatment-naive individuals were 34.8 years old, mostly males (95%), and with high smoking prevalence (70%). Baseline T CD4(+) was 512 & PLUSMN;324 cells/mcL. cfPWV was similar between HIV(-) and treatment-naive (6.8 vs 7.3 m/s; p = 0.16) but significantly decreased after ART (-0.52 m/s; 95% CI -0.87 to -0.16; p0.006). Almost all the determined cytokines were significantly higher compared to controls, except for MCP-1, myoglobin, NGAL, cystatin C, and MMP-9. At follow-up, only total cholesterol and triglycerides increased and all inflammatory cytokines significantly decreased. Regarding vascular cytokines, MPO, ICAM-1, and VCAM-1 showed a reduction. D-Dimer tended to decrease (p = 0.06) and hs-CRP did not show a significant reduction (p = 0.17). ConclusionOne year of ART had a positive effect on reducing inflammatory and vascular cytokines and arterial stiffness.

引用

页数：14

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