Comparative Effects of Different Nutritional Supplements on Inflammation, Nutritional Status, and Clinical Outcomes in Colorectal Cancer Patients: A Systematic Review and Network Meta-Analysis

被引:9
作者
Ye, Jiayi [1 ]
Hu, Yanjie [1 ]
Chen, Xinrong [1 ]
Chang, Chengting [1 ]
Li, Ka [1 ]
机构
[1] Sichuan Univ, West China Hosp, West China Sch Nursing, Chengdu 610041, Peoples R China
基金
中国国家自然科学基金;
关键词
nutritional supplements; colorectal cancer; inflammation; nutrition; network meta-analysis; QUALITY-OF-LIFE; POSTOPERATIVE INFECTIOUS COMPLICATIONS; POLYUNSATURATED FATTY-ACIDS; TOTAL PARENTERAL-NUTRITION; MICROBIAL CELL PREPARATION; ESMO CONSENSUS GUIDELINES; DOUBLE-BLIND; GLUTAMINE SUPPLEMENTATION; RECTAL-CANCER; GASTROINTESTINAL CANCER;
D O I
10.3390/nu15122772
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Nutritional supplements have been widely used in colorectal cancer (CRC) patients. The aim of this network meta-analysis (NMA) was to compare the effects of different nutritional supplements on inflammation, nutritional status, and clinical outcomes in CRC patients. Four electronic databases were searched until December 2022. Randomized controlled trials (RCTs) comparing nutritional supplements of omega-3 fatty acids (omega-3), arginine, vitamin D, glutamine, probiotics, or their combinations with placebo or standard treatment were selected. The outcomes were inflammatory indicators, nutritional indicators, and clinical outcomes. A random-effects Bayesian NMA was performed to rank the effect of each supplement. In total, 34 studies involving 2841 participants were included. Glutamine was superior in decreasing tumor necrosis factor-& alpha; (MD -25.2; 95% CrI [-32.62, -17.95]), whereas combined omega-3 and arginine supplementation was more effective in decreasing interleukin-6 (MD -61.41; 95% CrI [-97.85, -24.85]). No nutritional supplements significantly maintained nutritional indicators in CRC patients. Regarding clinical outcomes, glutamine ranked highest in reducing the length of hospital stay (MD -3.71; 95% CrI [-5.89, -1.72]) and the incidence of wound infections (RR 0.12; 95% CrI [0, 0.85]), and probiotics were rated as best in reducing the incidence of pneumonia (RR 0.38; 95% CrI [0.15, 0.81]). Future well-designed RCTs are needed to further confirm these findings.
引用
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页数:19
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