Decoding the regulatory roles of non-coding RNAs in cellular metabolism and disease

被引：28

作者：

Zong, Yuru ^{[1
]}

Wang, Xuliang ^{[2
,3
]}

Cui, Bing ^{[1
]}

Xiong, Xiaowei ^{[4
]}

Wu, Andrew ^{[5
]}

Lin, Chunru ^{[5
,6
]}

Zhang, Yaohua ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Inst Brain Disorders, Collaborat Innovat Ctr Brain Disorders, Lab Brain Disorders,Minist Sci & Technol, Beijing 100069, Peoples R China

[2] Peking Univ Third Hosp, Dept Cardiol, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100191, Peoples R China

[3] Peking Univ Third Hosp, Inst Vasc Med, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100191, Peoples R China

[4] Capital Med Univ, Beijing Tiantan Hosp, Dept Cardiol & Macrovasc Dis, Beijing 100050, Peoples R China

[5] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

[6] Univ Texas MD Anderson Canc Ctr, Grad Sch Biomed Sci, Houston, TX 77030 USA

来源：

MOLECULAR THERAPY | 2023年 / 31卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ATP CITRATE LYASE; GLUCOSE-TRANSPORTER; FATTY-ACID; PROMOTES GLYCOLYSIS; CARDIAC METABOLISM; TARGETING PPAR; CANCER CELLS; C-MYC; DEHYDROGENASE; PROGRESSION;

D O I：

10.1016/j.ymthe.2023.04.012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Non-coding RNAs, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), are being studied extensively in a variety of fields. Their roles in metabolism have received increasing attention in recent years but are not yet clear. The regulation of glucose, fatty acid, and amino acid metabolism is an imperative physiological process that occurs in living organisms and takes part in cancer and cardiovascular diseases. Here, we summarize the important roles played by non-coding RNAs in glucose metabolism, fatty acid metabolism, and amino acid metabolism, as well as the mechanisms involved. We also summarize the therapeutic advances for non-coding RNAs in diseases such as obesity, cardiovascular disease, and some metabolic diseases. Overall, non-coding RNAs are indispensable factors in metabolism and have a significant role in the three major metabolisms, which may be exploited as therapeutic targets in the future.

引用

页码：1562 / 1576

页数：15

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