Materials for Controlled Release of Local Anesthetics

被引：5
|
作者：
Li, Yang [1 ]
Owens, Gwen E. [1 ]
Kohane, Daniel S. [1 ]
机构：
[1] Harvard Med Sch, Childrens Hosp Boston, Dept Anesthesiol, Boston, MA 02115 USA
来源：
CHEMMEDCHEM | 2023年 / 18卷 / 11期
基金：
美国国家卫生研究院;
关键词：
Biocompatibility; controlled drug release; local anesthetics; microparticles and nanoparticles; opioid sparing; PROTEIN-SUGAR PARTICLES; SCIATIC-NERVE BLOCKADE; DRUG-DELIVERY; LIPOSOMAL BUPIVACAINE; IN-VIVO; SUSTAINED-RELEASE; TETRODOTOXIN; BIOCOMPATIBILITY; DEXAMETHASONE; TOXICITY;
D O I：
10.1002/cmdc.202300009
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Controlled release systems for prolonged duration local anesthesia have long been an area of research interest, and now are entering clinical practice, in part driven by the opioid epidemic. We discuss the design considerations and material properties of systems for controlled release of local anesthetics, from relatively simple systems to covalent binding of drugs to materials and delivery triggered by external stimuli.
引用
收藏
页数：7
相关论文
共 50 条
  • [11] Advances of Nano-Structured Extended-Release Local Anesthetics
    He, Yumiao
    Qin, Linan
    Huang, Yuguang
    Ma, Chao
    NANOSCALE RESEARCH LETTERS, 2020, 15 (01):
  • [12] Sustained release local anesthetics for pain management: relevance and formulation approaches
    Getachew, Melese
    Tesfaye, Hana
    Yihunie, Wubetu
    Ayenew, Tesfahun
    Alemu, Sintayehu
    Dagnew, Ephrem Mebratu
    Biyazin, Yalemgeta
    Abebe, Dehnnet
    Degefu, Natanim
    Abebaw, Abtie
    FRONTIERS IN PAIN RESEARCH, 2024, 5
  • [13] Glutamate release and neuronal injury after intrathecal injection of local anesthetics
    Ohtake, K
    Matsumoto, M
    Wakamatsu, H
    Kawai, K
    Nakakimura, K
    Sakabe, T
    NEUROREPORT, 2000, 11 (05) : 1105 - 1109
  • [14] Advances of Nano-Structured Extended-Release Local Anesthetics
    Yumiao He
    Linan Qin
    Yuguang Huang
    Chao Ma
    Nanoscale Research Letters, 2020, 15
  • [15] Local Anesthetics
    Golembiewski, Julie
    JOURNAL OF PERIANESTHESIA NURSING, 2013, 28 (06) : 409 - 412
  • [16] Local anesthetics
    Hirschfelder, AD
    Bieter, RN
    PHYSIOLOGICAL REVIEWS, 1932, 12 (02) : 0190 - 0282
  • [17] Local Anesthetics
    Faure, Sebastien
    ACTUALITES PHARMACEUTIQUES, 2010, 49 (493): : 49 - 52
  • [18] Local anesthetics
    Heavner, James E.
    CURRENT OPINION IN ANESTHESIOLOGY, 2007, 20 (04) : 336 - 342
  • [19] LOCAL ANESTHETICS
    VANDAM, LD
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1962, 3 (01) : 131 - &
  • [20] LOCAL ANESTHETICS
    不详
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1950, 143 (13): : 1221 - 1221
12345