Materials for Controlled Release of Local Anesthetics

被引：5

作者：

Li, Yang ^{[1
]}

Owens, Gwen E. ^{[1
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Med Sch, Childrens Hosp Boston, Dept Anesthesiol, Boston, MA 02115 USA

来源：

CHEMMEDCHEM | 2023年 / 18卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Biocompatibility; controlled drug release; local anesthetics; microparticles and nanoparticles; opioid sparing; PROTEIN-SUGAR PARTICLES; SCIATIC-NERVE BLOCKADE; DRUG-DELIVERY; LIPOSOMAL BUPIVACAINE; IN-VIVO; SUSTAINED-RELEASE; TETRODOTOXIN; BIOCOMPATIBILITY; DEXAMETHASONE; TOXICITY;

D O I：

10.1002/cmdc.202300009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Controlled release systems for prolonged duration local anesthesia have long been an area of research interest, and now are entering clinical practice, in part driven by the opioid epidemic. We discuss the design considerations and material properties of systems for controlled release of local anesthetics, from relatively simple systems to covalent binding of drugs to materials and delivery triggered by external stimuli.

引用

页数：7

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