Serum lipid biomarkers and inflammatory cytokines associated with onset and clinical status of patients with early knee osteoarthritis

被引:10
作者
Herrero-Manley, Luz [1 ]
Alabajos-Cea, Ana [1 ,2 ]
Suso-Marti, Luis [3 ]
Cuenca-Martinez, Ferran [4 ]
Calatayud, Joaquin [3 ]
Casana, Jose [3 ]
Viosca-Herrero, Enrique [1 ]
Vazquez-Arce, Isabel [1 ]
Jose Ferrer-Sargues, Francisco [5 ]
Blanco-Diaz, Maria [6 ]
机构
[1] Hosp La Fe, Serv Med Fis & Rehabil, Valencia, Spain
[2] Inst Invest Sanitaria La Fe IISLAFE, Grp Invest Med Fis & Rehabil, Valencia, Spain
[3] Univ Valencia, Dept Physiotherapy, Exercise Intervent Hlth Res Grp EXINH RG, Valencia, Spain
[4] Univ Valencia, Dept Physiotherapy, Valencia, Spain
[5] Univ Cardenal Herrera CEU Univ, Dept Physiotherapy, Valencia, Spain
[6] Univ Oviedo, Fac Med & Hlth Sci, Dept Surg & Med Surg Specialties, Oviedo, Spain
基金
欧盟地平线“2020”;
关键词
osteoarthritis; early osteoarthritis; serum lipid; inflammatory biomarkers; cytokine; C-REACTIVE PROTEIN; WALKING SPEED; FUNCTIONAL STATUS; REFERENCE VALUES; RISK-FACTORS; CHOLESTEROL; ADULTS; PATHOPHYSIOLOGY; EPIDEMIOLOGY; RELIABILITY;
D O I
10.3389/fnut.2023.1126796
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
IntroductionOsteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of serum lipid and inflammatory biomarkers in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. The primary aim of this study was to evaluate differences of serum lipid and inflammatory biomarkers with knee EOA in comparison with matched controls, in order to determine the role of these factors in the origin of EOA. MethodsFor this proposal, a cross-sectional study with a non-randomized sample was performed. 48 subjects with early osteoarthritis (EOA) and 48 matched controls were selected and serum lipid levels (total cholesterol, LDL, HDL) and inflammatory biomarkers C-reactive protein (CRP), uric acid (UA) were analyzed. In addition, clinical (pain, disability) and functional (gait speed, sit-to-stand) variables were measured to establish their relationship to serum lipid levels and inflammatory biomarkers. ResultsPatients with EOA showed higher levels of total cholesterol LDL, UA, and CRP. Higher levels of total cholesterol, LDL and CRP were correlated with higher levels of pain intensity and higher disability (p < 0.05). In addition, UA and CRP were inversely correlated with gait speed and sit-to-stand tests (r = -0.038 to -0.5, p < 0.05). ConclusionThese results highlight the relevance of metabolic and proinflammatory aspects in the early stages of knee OA and could be key to developing early diagnoses to prevent the onset and development of the disease.
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页数:7
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