FGFR1 is an important prognostic factor in oral leukoplakia and tongue squamous cell carcinoma

被引：2

作者：

Mariz, Bruno Augusto Linhares Almeida ^{[1
,5
]}

de Sa, Raisa Sales ^{[1
]}

Araujo, Anna Luiza Damaceno ^{[1
]}

Fernandes, Carla Isabelly Rodrigues ^{[1
]}

Mariano, Fernanda Viviane ^{[2
]}

Santos-Silva, Alan Roger ^{[1
]}

Lopes, Marcio Ajudarte ^{[1
]}

Vargas, Pablo Agustin ^{[1
]}

de Almeida, Oslei Paes ^{[1
]}

Kowalski, Luiz Paulo ^{[3
,4
]}

Jorge, Jacks ^{[1
]}

机构：

[1] Univ Campinas UNICAMP, Piracicaba Dent Sch, Oral Diag Dept, Piracicaba, Brazil

[2] Univ Campinas UNICAMP, Fac Med Sci, Dept Pathol, Campinas, Brazil

[3] A C Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo, Brazil

[4] Univ Sao Paulo, Med Sch, Head & Neck Surg Dept, Sao Paulo, Brazil

[5] Univ Estadual Campinas, Piracicaba Dental Sch, Oral Diag Dept, OralPathol Lab, 901, Ave Limeira, Areao, BR-13414903 Sao Paulo, Brazil

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2023年 / 52卷 / 02期

关键词：

AKT; FGFR1; immunohistochemistry; oral cancer; oral leukoplakia; HEAD; AMPLIFICATION; DYSPLASIA;

D O I：

10.1111/jop.13398

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Background: Fibroblast growth factor receptor 1 is a potential prognostic factor for tongue squamous cell carcinoma and is associated with oral epithelial dysplasia grade in oral leukoplakia.Methods: Thirty cases of tongue squamous cell carcinoma and 30 cases of oral leukoplakia were analyzed. Fibroblast growth factor receptor 1 and phosphorylated Akt protein expression were analyzed by immunohistochemistry and quantified using a digital algorithm. Fibroblast growth factor receptor 1 gene amplification was analyzed by fluorescent in situ hybridization in the tongue squamous cell carcinoma cases.Results: Clinical appearance and dysplasia grade were correlated with oral leukoplakia malignant transformation. Oral leukoplakia cases presenting high fibroblast growth factor receptor 1 expression showed a higher risk of malignant transformation (p = 0.016, HR: 7.3, 95% CI: 1.4-37.4). Phosphorylated Akt showed faint to no expression in oral leukoplakia, which did not correlate with dysplasia grade or malignant transformation. High expression of fibroblast growth factor receptor 1 and phosohorylated Akt were associated with poor overall survival and disease-free survival in tongue squamous cell carcinoma, although only fibroblast growth factor receptor 1 expression was significantly associated with poor overall survival (p = 0.024; HR: 4.9, 95% CI: 1.2-19.9). Cases presenting double fibroblast growth factor receptor 1/phosphorylated Akt overexpression (n = 8) showed markedly impaired overall survival (p = 0.020; HR: 6.4, 95% CI: 1.3-31.1) and disease-free survival (p = 0.001, HR: 13.0, 95% CI: 3.0-55.7). Fibroblast growth factor receptor 1 amplification was observed in 16.6% of tongue squamous cell carcinoma cases, being correlated with vascular and neural invasion (p = 0.001 and 0.017, respectively), but not with fibroblast growth factor receptor 1 protein expression, overall survival, or disease-free survival.Conclusion: Fibroblast growth factor receptor 1 protein expression is an important prognostic factor in oral leukoplakia and tongue squamous cell carcinoma.

引用

页码：119 / 126

页数：8

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