Pharmacological agents for defatting livers by normothermic machine perfusion

被引:1
|
作者
Li, Shu-xuan [1 ]
Chen, Lanlan [1 ]
Li, Ming-qian [1 ,2 ]
Lv, Guo-yue [1 ,2 ]
机构
[1] First Hosp Jilin Univ, Dept Hepatobiliary & Pancreat Surg, Jilin, Peoples R China
[2] First Hosp Jilin Univ, Dept Hepatobiliary & Pancreat Surg, 1 Xinmin St, Changchun 130021, Jilin, Peoples R China
关键词
defatting; ex vivo perfusion; liver perfusion; normothermic machine perfusion; phenolic compounds; steatosis; HYPOTHERMIC OXYGENATED PERFUSION; HEPATIC STEATOSIS; PPAR-ALPHA; LIPID-METABOLISM; FATTY LIVER; TRANSPLANTATION; RECEPTOR; AGONIST; OBESITY; MICE;
D O I
10.1111/aor.14478
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
BackgroundEx-vivo normothermic machine perfusion (NMP) preserves the liver metabolism at 37 degrees C and has rapidly developed as a promising approach for assessing the viability and improving the performance of organs from expanded criteria donors, including fatty liver grafts. NMP is an effective method for defatting fatty livers when combined with pharmaceutical therapies. Pharmacological agents have been shown to facilitate liver defatting by NMP. ObservationsThis systematic review summarizes available pharmacological therapies for liver defatting, with a particular emphasis on defatting agents that can be employed clinically as defatting components during liver NMP as an ex vivo translational paradigm. ConclusionNMP provides an opportunity for organ treatment and can be used as a defatting platform in the future with defatting agents. Nagrath's cocktail is the most commonly used defatting cocktail in NMP; however, its carcinogenic components may limit its clinical application. Thus, the combination of a defatting cocktail with a new clinically applicable component, for example, a polyphenolic natural compound, may be a novel pharmacological option.
引用
收藏
页码:925 / 933
页数:9
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