Comparison of Comprehensive Screening Results in Postmortem Blood and Brain Tissue by UHPLC-QTOF-MS

被引：4
|
作者：
Hansen, Stine Lund [1 ]
Dalsgaard, Petur Weihe [1 ]
Linnet, Kristian [1 ]
Rasmussen, Brian Schou [1 ]
机构：
[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Forens Med, Sect Forens Chem, Frederik Vs Vej 11, DK-2100 Copenhagen O, Denmark
来源：
JOURNAL OF ANALYTICAL TOXICOLOGY | 2023年 / 46卷 / 09期
关键词：
LIQUID-CHROMATOGRAPHY; TOXICOLOGY; SAMPLES; DRUGS; QUANTIFICATION;
D O I：
10.1093/jat/bkac011
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Alternative specimens collected during autopsies can be valuable in postmortem toxicology in cases where peripheral blood is not available. The applicability of brain tissue as an alternative matrix for drug screening by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry was investigated in this study. Results of the 50 most frequently detected drugs and metabolites of toxicological interest in blood and brain tissue samples from 1,719 autopsy cases were compared. Examination of the results in paired blood and brain tissue samples revealed that the two matrices were in general comparable, as the majority of the 50 analytes were observed in a high number of the examined cases in both blood and brain tissue. This demonstrates the potential of brain tissue as an alternative matrix for drug screening in postmortem toxicology or as a secondary matrix for confirmation.
引用
收藏
页码：1053 / 1058
页数：6
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