Partial reprogramming of the mammalian brain

被引:0
作者
Asmussen, Niels C. [1 ,2 ]
Schafer, Marissa J. [1 ,2 ,3 ]
机构
[1] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA
[2] Mayo Clin, Robert & Arlene Kogod Ctr Aging, Rochester, MN 55905 USA
[3] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA
来源
NATURE AGING | 2024年 / 4卷 / 04期
基金
美国国家卫生研究院;
关键词
VIVO; CELLS;
D O I
10.1038/s43587-024-00596-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Xu and colleagues used partial OSKM reprogramming in aged mice to drive cell-type proportions of the subventricular zone to more youthful levels, which equates to qualified rejuvenation of a neurogenic niche that is defined, in part, by restoration of neuroblast levels.
引用
收藏
页码:440 / 442
页数:3
相关论文
共 15 条
  • [1] Reprogramming in vivo produces teratomas and iPS cells with totipotency features
    Abad, Maria
    Mosteiro, Lluc
    Pantoja, Cristina
    Canamero, Marta
    Rayon, Teresa
    Ors, Inmaculada
    Grana, Osvaldo
    Megias, Diego
    Dominguez, Orlando
    Martinez, Dolores
    Manzanares, Miguel
    Ortega, Sagrario
    Serrano, Manuel
    [J]. NATURE, 2013, 502 (7471) : 340 - +
  • [2] Mechanisms of enhanced quiescence in neural stem cell aging
    Audesse, Amanda J.
    Webb, Ashley E.
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 2020, 191
  • [3] In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice
    Browder, Kristen C.
    Reddy, Pradeep
    Yamamoto, Mako
    Haghani, Amin
    Guillen, Isabel Guillen
    Sahu, Sanjeeb
    Wang, Chao
    Luque, Yosu
    Prieto, Javier
    Shi, Lei
    Shojima, Kensaku
    Hishida, Tomoaki
    Lai, Zijuan
    Li, Qingling
    Choudhury, Feroza K.
    Wong, Weng R.
    Liang, Yuxin
    Sangaraju, Dewakar
    Sandoval, Wendy
    Esteban, Concepcion Rodriguez
    Nunez Delicado, Estrella
    Guillen Garcia, Pedro
    Pawlak, Michal
    Vander Heiden, Jason A.
    Horvath, Steve
    Jasper, Heinrich
    Belmonte, Juan Carlos Izpisua
    [J]. NATURE AGING, 2022, 2 (03): : 243 - +
  • [4] Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain
    Buckley, Matthew T.
    Sun, Eric D. D.
    George, Benson M.
    Liu, Ling
    Schaum, Nicholas
    Xu, Lucy
    Reyes, Jaime M.
    Goodell, Margaret A.
    Weissman, Irving L.
    Wyss-Coray, Tony
    Rando, Thomas A.
    Brunet, Anne
    [J]. NATURE AGING, 2023, 3 (01): : 121 - +
  • [5] Rejuvenating subventricular zone neurogenesis in the aging brain
    Cutler, Ronald R.
    Kokovay, Erzsebet
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2020, 50 : 1 - 8
  • [6] Pleiotrophin antagonizes Brd2 during neuronal differentiation
    Garcia-Gutierrez, Pablo
    Juarez-Vicente, Francisco
    Wolgemuth, Debra J.
    Garcia-Dominguez, Mario
    [J]. JOURNAL OF CELL SCIENCE, 2014, 127 (11) : 2554 - 2564
  • [7] The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules
    Nam, Jungyong
    Mah, Won
    Kim, Eunjoon
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2011, 22 (05) : 492 - 498
  • [8] In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
    Ocampo, Alejandro
    Reddy, Pradeep
    Martinez-Redondo, Paloma
    Platero-Luengo, Aida
    Hatanaka, Fumiyuki
    Hishida, Tomoaki
    Li, Mo
    Lam, David
    Kurita, Masakazu
    Beyret, Ergin
    Araoka, Toshikazu
    Vazquez-Ferrer, Eric
    Donoso, David
    Roman, Jose Luis
    Xu, Jinna
    Esteban, Concepcion Rodriguez
    Nunez, Gabriel
    Nunez Delicado, Estrella
    Campistol, Josep M.
    Guillen, Isabel
    Guillen, Pedro
    Belmonte, Juan Carlos Izpisua
    [J]. CELL, 2016, 167 (07) : 1719 - +
  • [9] Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation
    Ohnishi, Kotaro
    Semi, Katsunori
    Yamamoto, Takuya
    Shimizu, Masahito
    Tanaka, Akito
    Mitsunaga, Kanae
    Okita, Keisuke
    Osafune, Kenji
    Arioka, Yuko
    Maeda, Toshiyuki
    Soejima, Hidenobu
    Moriwaki, Hisataka
    Yamanaka, Shinya
    Woltjen, Knut
    Yamada, Yasuhiro
    [J]. CELL, 2014, 156 (04) : 663 - 677
  • [10] Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age
    Palmer, Raymond D.
    [J]. AGING MEDICINE, 2022, 5 (02) : 120 - 125