Post-Transplant Glomerulonephritis: Challenges and Solutions

被引:0
作者
de Sousa, Marcos Vinicius [1 ,2 ]
机构
[1] Univ Estadual Campinas, Sch Med Sci, Div Nephrol, Dept Internal Med,Transplant Res Lab,Renal Transpl, Campinas, SP, Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Div Nephrol, Renal Transplant Unit, Rua Tessalia Vieira de Camargo 126,Cidade Univ Zef, BR-13083970 Campinas, SP, Brazil
来源
INTERNATIONAL JOURNAL OF NEPHROLOGY AND RENOVASCULAR DISEASE | 2024年 / 17卷
关键词
glomerulonephritis; viral infection; kidney transplantation; chronic kidney disease; NOVO MEMBRANOUS NEPHROPATHY; RECURRENT IGA NEPHROPATHY; ANTIBODY-MEDIATED REJECTION; KIDNEY-TRANSPLANTATION; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; OXFORD CLASSIFICATION; RENAL-ALLOGRAFT; HEPATITIS; UPDATE; VIRUS;
D O I
10.2147/IJNRD.S391779
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Glomeruli can be damaged in several conditions after kidney transplantation, with a potential impact on the graft function and survival. Primary glomerulonephritis, a group of glomerular immunological damage that results in variable histological patterns and clinical phenotypes, can occur in kidney transplant recipients as a recurrent or de novo condition. Specific immunologic conditions associated with kidney transplantation, such as acute rejection episodes, can act as an additional trigger after transplantation, impacting the incidence of these glomerulopathies. The post-transplant GN recurrence ranges from 3% to 15%, varying according to the GN subtype and post-transplant time, mainly occurring after 3-5 years of kidney transplantation. Advances in the knowledge of glomerulonephritis pathophysiology have provided new approaches to pre-transplant risk evaluation and post-transplant monitoring. Glomeruli can be affected by several systemic viral infections, such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), cytomegalovirus (CMV), and BK virus. The diagnosis of these infections, as well as the identification of possible complications associated with them, are important to minimize the negative impacts of these conditions on kidney transplant recipients' outcomes.
引用
收藏
页码:81 / 90
页数:10
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