Co (II), Ni (II), and Cu (II) ternary complexes with 2,6-pyridinedicarboxylic acid: Thermal decomposition, DNA interaction, and biological activity studies

Three novel ternary complexes [MII (PDA)(o-phen)(H2O)] (MII = CoII, NiII, and CuII) were synthesized using 2,6-pyridinedicarboxylicacid as a primary ligand and 1,10-phenanthroline(o-phen) as the auxiliary ligand and analyzed by FT-IR, mass, UV-Vis, thermogravimetry analysis, and conductivity measurement data. Based on electronic spectral measurements, all three of the metal complexes were found to have octahedral stereochemistry. The way metal complexes interact with ct-DNA was studied using various methods including absorption spectroscopy, fluorescence spectroscopy, and viscosity measurements. UV-Vis absorption technique has been used to explore the binding characteristics of M (II) complexes with ct-DNA. The complexes bind to DNA via groove mode of binding, according to the spectral data. The salt-dependent binding of ternary metal complexes to ct-DNA has been studied by UV-Vis spectrophotometric titration experiment. Furthermore, gel electrophoresis is used to examine how the metal complexes interacted with the pBR322 DNA. The outcomes showed that these compounds can function as efficient DNA cleaving agents. Studies on the complexes' in vitro antibacterial activity demonstrated their importance and good antimicrobial activity at three distinct concentrations (50, 75, and 100 g/mL). The studies reveal that the metal complex could attach to ct-DNA successfully through groove binding mode. Studies on the complexes' in vitro antibacterial activity demonstrated their importance and good antimicrobial activity at three distinct concentrations. image