Circulating osteoprotegerin levels and cardiovascular outcomes in patients with pre-dialysis chronic kidney disease: results from the KNOW-CKD study

被引：0

作者：

Suh, Sang Heon ^{[1
,2
]}

Oh, Tae Ryom ^{[1
,2
]}

Choi, Hong Sang ^{[1
,2
]}

Kim, Chang Seong ^{[1
,2
]}

Bae, Eun Hui ^{[1
,2
]}

Ma, Seong Kwon ^{[1
,2
]}

Oh, Kook-Hwan ^{[3
]}

Lee, Kyu-Beck ^{[4
]}

Jeong, Jong Cheol ^{[5
]}

Jung, Ji Yong ^{[6
]}

Kim, Soo Wan ^{[1
,2
]}

机构：

[1] Chonnam Natl Univ, Dept Internal Med, Med Sch, 42 Jebongro, Gwangju 61469, South Korea

[2] Chonnam Natl Univ Hosp, 42 Jebongro, Gwangju 61469, South Korea

[3] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea

[4] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Nephrol,Sch Med, Seoul, South Korea

[5] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Div Nephrol, Seongnam, South Korea

[6] Gachon Univ, Gil Med Ctr, Dept Internal Med, Div Nephrol, Incheon, South Korea

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Biomarker; Chronic kidney disease; Major adverse cardiac event; Osteoprotegerin; CORONARY-ARTERY CALCIFICATION; SERUM OSTEOPROTEGERIN; HEART-FAILURE; PLASMA OSTEOPROTEGERIN; RISK; MORTALITY; EVENTS; BIOMARKERS; BONE; ASSOCIATION;

D O I：

10.1038/s41598-024-54335-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

While the relationship between circulating osteoprotegerin (OPG) and cardiovascular events is well-established in the general population, its association with cardiovascular risks in chronic kidney disease (CKD) patients remains less robust. This study hypothesized that elevated circulating OPG levels might be associated with an increased risk of major adverse cardiac events (MACE) in CKD patients, a total of 2,109 patients with CKD stages 1 through pre-dialysis 5 from the KNOW-CKD cohort were categorized into quartiles based on serum OPG levels. The primary outcome of the study was 3-point MACE, defined as a composite of nonfatal myocardial infarction, nonfatal stroke, or cardiac death. The median follow-up duration was 7.9 years. The cumulative incidence of 3-point MACE significantly varied across serum OPG levels in Kaplan-Meier curve analysis (P < 0.001, log-rank test), with the highest incidence observed in the 4th quartile. Cox regression analysis indicated that, relative to the 1st quartile, the risk of 3-point MACE was significantly higher in the 3rd (adjusted hazard ratio 2.901, 95% confidence interval 1.009 to 8.341) and the 4th quartiles (adjusted hazard ratio 4.347, 95% confidence interval 1.410 to 13.395). In conclusion, elevated circulating OPG levels are associated with adverse cardiovascular outcomes in pre-dialysis CKD patients.

引用

页数：11

共 41 条

[31] Heart failure and kidney dysfunction: epidemiology, mechanisms and management [J].