A personalized approach to lymphoproliferations in patients with inborn errors of immunity

被引:3
作者
Naor, Shachar [1 ]
Adam, Etai [2 ]
Schiby, Ginette [1 ]
Gratzinger, Dita [3 ]
机构
[1] Sheba Med Ctr, Inst Pathol, Ramat Gan, Israel
[2] Edmond & Lily Safra Childrens Hosp, Sheba Med Ctr, Div Pediat Hematol & Oncol, Ramat Gan, Israel
[3] Stanford Univ, Dept Pathol, Stanford, CA USA
关键词
WISKOTT-ALDRICH-SYNDROME; 3-KINASE DELTA SYNDROME; NON-HODGKINS-LYMPHOMA; COMBINED IMMUNODEFICIENCY; CELL LYMPHOMA; DEFICIENCY; MUTATIONS; DISEASE; PREDISPOSITION; DYSREGULATION;
D O I
10.1053/j.semdp.2023.07.001
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Biopsies from patients with inborn error of immunity (IEI) may pose a diagnostic challenge due to the abnormal anatomy of their lymphoid organs and the tendency for the development of lymphoproliferations in various organs, some of which may lead to the wrong impression of malignant lymphoma which may prompt aggressive unnecessary treatment. In this article we will review typical histologic findings in various IEI's described in the literature and discuss the appropriate approach to the diagnosis of lymphoproliferations in these patients by presenting illustrative cases.
引用
收藏
页码:408 / 419
页数:12
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