The efficacy of HDDPiW-jS']jSB solution on docetaxel-induced alopecia of rats

被引：1

作者：

Demir, Bilgin ^{[1
,5
]}

Demirci, Buket ^{[2
]}

Tataroglu, Canten ^{[3
]}

Barutca, Sabri ^{[1
]}

Barutca, Duygu ^{[4
]}

机构：

[1] Aydın Adnan Menderes Univ, Med Fac, Dept Internal Med, Div Med Oncol, Aydin, Turkiye

[2] Aydın Adnan Menderes Univ, Med Fac, Dept Med Pharmacol, Aydin, Turkiye

[3] Aydın Adnan Menderes Univ, Med Fac, Dept Med Pathol, Aydin, Turkiye

[4] Izmir Univ Econ, Fac Engn, Ind Engn, Izmir, Turkiye

[5] Aydin Adnan Menderes Univ, Dept Med Oncol, Fac Med, TR-09100 Aydin, Turkiye

来源：

CUTANEOUS AND OCULAR TOXICOLOGY | 2024年 / 43卷 / 02期

关键词：

Chemotherapy induced alopecia; docetaxel; hair loss; oncology; animal research; HAIR-FOLLICLES; CHEMOTHERAPY; DOXORUBICIN; APOPTOSIS; GROWTH; MICE;

D O I：

10.1080/15569527.2023.2300790

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

ObjectiveChemotherapy induced alopecia (CIA) is one of the most common side effects in cancer patients, however; it doesn't have an effective pharmacological treatment yet. In this study we aimed to research the protective effect of newly developed HDDPiW-jSB solution on docetaxel (DTX) -induced rat alopecia model.Material and MethodsDocetaxel (10 mg/kg/week) was administered to the 6-8 months old rats for three weeks. HDDPiW-jSB solution was applied once or twice a week for 4 weeks beginning prior to one week before DTX. Rat hair follicles were evaluated with hematoxylin-eosin and immune-histochemical staining.ResultsIn the first stage of this study, alopecia was successfully developed by DTX (10 mg/kg/three times) application. In the second stage of the study, application of HDDPiW-jSB solution, did not change the study parameters significantly on control group. The solution improved the anagen hair follicle count and Bcl-2 levels in the skin samples of DTX-induced alopecic rat groups, especially when applied twice weekly. Additionally, level of Caspase 3 was decreased. HDDPiW-jSB solution was safe when applied on the skin.ConclusionTopical HDDPiW-jSB solution could be effective and safe for the protection of DTX-induced alopecia in rat models.

引用

页码：113 / 119

页数：7

共 27 条

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